Heart Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Group A (people with a medical reason for a heart MRI):

• People aged 18 or older, of any gender, who are willing and able to sign a consent form and take part for the full length of the study
• People who are already scheduled for a medically necessary heart MRI — for example, due to conditions such as heart failure, chest pain, unexplained breathlessness, valve problems, heart defects, tumours near the heart, aortic disease, exposure to drugs known to affect the heart, or other illnesses that can affect the heart

Group B (healthy volunteers, for testing and building reference data):

• People aged 18 or older, of any gender, who are willing and able to sign a consent form and take part for the full length of the study

Who may not be able to join:

• People who cannot safely have an MRI scan due to certain metal implants or devices in their body, such as brain aneurysm clips, nerve stimulators, pacemakers or defibrillators, cochlear (ear) implants, insulin pumps, metal fragments in the eyes, or metal shrapnel or bullets — unless the trial site has assessed those devices as safe for MRI
• People with severely reduced kidney function (confirm with trial site for exact measurement) who are scheduled to receive a standard MRI contrast dye called GBCA
• People with a known allergy to GBCA contrast dye, if that dye is part of the planned scan
• People with a known allergy to ferumoxytol (an alternative contrast agent) or to mannitol (an ingredient in ferumoxytol), if ferumoxytol is part of the planned scan
• People scheduled for a stress test using the medications adenosine or regadenoson, who have certain heart or lung conditions — including a breathing condition with active wheezing, certain heart rhythm problems without a suitable pacemaker, very low or very high blood pressure, or a known allergy to those medications
• People who have taken a blood-thinning medication called dipyridamole within the past 48 hours, if a stress test with adenosine or regadenoson is planned
• People with unstable chest pain, a recent heart attack, or an active heart emergency
• People with a seizure disorder, if regadenoson is the planned stress medication
• People who are pregnant
• Women who are breastfeeding and are scheduled to receive GBCA contrast dye, unless they are willing to discard their breast milk for 24 hours after receiving the dye

Additional exclusions for Group B (healthy volunteers) only:

• People with a known history of significant illness, including high blood pressure requiring medication, heart attack, diabetes, inherited high cholesterol, heart muscle disease, congenital heart conditions, moderate or severe heart valve disease, stroke, peripheral vascular disease, symptoms of chest pain or breathlessness, or current smoking
• People who are not able to make their own decisions about participating

Important: Always verify eligibility with the trial site directly before applying.