Phase 2 Liver Cancer Trial, Recruiting NCT04965454 Sponsor: Queen's Medical Center Condition: Liver Cancer
Back to Liver Cancer

Phase 2 Liver Cancer Trial, Recruiting

NCT04965454
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 or older (there is no upper age limit)
  • People who have been diagnosed with hepatocellular carcinoma (a type of liver cancer) confirmed either by tissue sample or by imaging scans, following specific cancer network guidelines
  • People whose cancer cannot be treated with surgery or local treatments alone, or whose cancer has come back or grown after surgery and/or local treatments
  • People who have at least one tumour that can be clearly measured on a CT or MRI scan taken within the past 6 weeks
  • People who are currently being cared for by a licensed cancer specialist (medical oncologist)
  • People with a life expectancy of more than 6 months
  • People whose treating oncologist considers them suitable for a type of cancer treatment that works with the immune system (called an immune checkpoint inhibitor), based on their treatment history, overall health, and organ function
  • People with a Child-Pugh score of 9 or less (a measure of liver function — confirm with trial site if unsure)
  • People whose kidneys are filtering at a rate of at least 40 mL/min, as measured by a specific formula
  • People whose liver enzyme levels (ALT and AST) are within 7 times the normal upper limit
  • People whose total bilirubin level is 4 mg/dL or lower
  • People whose albumin (a blood protein) level is 2.8 g/dL or higher

Who may not be able to join:

  • People who weigh more than 500 lbs (approximately 227 kg), due to the weight limit of the PET/CT scanner used in this trial
  • People who are pregnant or breastfeeding (people of childbearing potential will need to be re-screened within 7 days before the PET/CT scan)
  • People with a serious underlying health condition that would make it difficult to tolerate the imaging procedure used in the trial
  • People currently receiving a non-targeted cancer treatment (note: taking part in another immune checkpoint inhibitor trial, or receiving a combination of immune checkpoint inhibitor treatments, is permitted)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Sandi A Kwee, MD, PhD, The Queen's Medical Center

Phone: 808-691-7429

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Queen's Medical Center
Registry
ClinicalTrials.gov
Start date
28 March 2022
Est. completion
31 December 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Lack of Objective Response

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov