Phase 4 Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with primary Sjögren's syndrome (pSS) based on the 2016 international classification criteria for this condition.
• People who experience symptoms of dry mouth and dry eyes.
• People whose blood test at the screening stage shows a positive result for a specific antibody called anti-SSA/Ro-60.
• People whose blood test shows a protein called IgG at a level of 16 g/L or higher.
• People who have not taken hormones, immunosuppressants, biological medicines, or similar treatments in the 4 weeks before screening.
• Women whose pregnancy test result is negative at screening, and who agree to use effective contraception throughout the trial.
• People who have not taken part in any other drug trial in the 12 weeks before joining.

Who may not be able to join:

• Women who are pregnant, breastfeeding, or planning to become pregnant during the study.
• People who have another connective tissue disease alongside their Sjögren's syndrome.
• People who have or have had a cancer diagnosis.
• People with a mental illness, a history of alcohol or drug/substance misuse, a weakened immune system, or an infection that is not under control.
• People whose condition requires additional strong medications to manage, or who have serious involvement of major organs — such as the heart, liver, kidneys, lungs, or blood — with specific abnormal test results in those areas (confirm with trial site for exact thresholds).
• People who have lesions affecting the back of the eye or visual field.
• People who have a known allergy to any ingredient in the study medicines (IGU and/or HCQ).
• People whom the trial investigator considers unsuitable for the study for any reason.

Important: Always verify eligibility with the trial site directly before applying.