Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between the ages of 19 and 79 years old
• People who have signed a consent form agreeing to take part in the trial
• People diagnosed with liver cancer (hepatocellular carcinoma) confirmed by MRI, contrast-enhanced CT scan showing a liver lesion larger than 1 cm, or by tissue biopsy if scan results were unclear
• People for whom surgery to remove the tumour, a procedure to destroy the tumour through the skin, or a liver transplant is not considered appropriate at the time of joining the trial
• People whose liver cancer is classified as Child-Pugh A or B (a measure of liver function), with tumours between 1 cm and 10 cm in size, between 1 and 7 tumours in total, no involvement of blood vessels, and who are reasonably physically active (ECOG score of 0 or 1, meaning able to carry out normal daily activities with at most mild limitations)
• People whose liver cancer has come back after previous treatment and who are not suitable for surgery or tumour removal
• People who are expected to live at least 6 months and are able to attend follow-up appointments until the trial ends

Who may not be able to join:

• People under the age of 19
• People with severe kidney disease (chronic kidney disease grade 4 or 5)
• People who have already received chemotherapy, radiation therapy, sorafenib (a cancer medication), or a specific type of chemoembolization called drug-eluting TACE (deTACE) for their liver cancer
• Women who are pregnant, breastfeeding, pre-menopausal, and not using an effective form of contraception
• People with a low physical activity level as measured by an ECOG score greater than 1 (meaning significant limitations in daily activity)
• People whose liver function is classified as Child-Pugh Class C (indicating poor liver function)
• People whose liver cancer has spread into blood vessels or to other parts of the body outside the liver
• People with active bleeding in the stomach or intestines
• People with a known, permanent inability for their blood to clot properly
• People with a brain condition called encephalopathy that is not adequately controlled with medication
• People with a build-up of fluid in the abdomen (ascites) that is not controlled with medication
• People who are unable to have an MRI or CT scan, for example due to metal implants in the body
• People with an allergy to contrast dye used in scans that cannot be managed with preventive treatment
• People for whom angiography (an imaging procedure involving blood vessels) is not medically appropriate
• People for whom the cancer medication cisplatin is not medically appropriate
• People for whom a procedure called hepatic artery embolization (blocking blood supply to the tumour) is not medically appropriate — this includes people with large abnormal connections between blood vessels, abnormal blood flow in the liver, or certain elevated blood test results (bilirubin above 3.0 mg/dL or creatinine above 2.0 mg/dL), or irreversible blood clotting disorders
• People whom the trial's lead doctor determines are not suitable to participate for any other medical reason

Important: Always verify eligibility with the trial site directly before applying.