Phase 2 Hearing Loss Trial, Recruiting (NCT05129748)

Phase 2 Hearing Loss Trial, Recruiting NCT05129748 Sponsor: Sunnybrook Health Sciences Centre Condition: Hearing Loss

Printed from Voxsanity (voxsanity.com.au) — NCT05129748 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Hearing Loss

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

You are receiving cisplatin (a type of chemotherapy) as part of your cancer treatment
You are 18 years old or older
You are willing to sign a consent form agreeing to take part
You are reasonably well and able to carry out daily activities with little or no help (confirm with trial site)
If you could become pregnant, you have had a negative pregnancy test before starting the study treatment
If you are able to have children (male or female), you agree in writing to use reliable contraception for the entire duration of the trial

Who may not be able to join:

You are under 18 years old
You already have a significant hearing loss in one or both ears, as confirmed by a hearing test
You have a history of Meniere's disease or a condition that causes your hearing to change or fluctuate over time
You have a noticeable difference in hearing ability between your two ears (confirm with trial site)
Your kidneys are not working well enough (confirm with trial site)
Your liver is not functioning within acceptable levels, based on blood tests (confirm with trial site)
You have previously had an allergic reaction to STS (sodium thiosulfate) or mannitol
You are currently pregnant or breastfeeding
For any reason, you would not be able to follow the trial's requirements

⚠️ Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 23 July 2026

Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.

Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 1-416-480-6100

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT05129748

Sponsor: Sunnybrook Health Sciences Centre

Phase: Phase 2

Status: Recruiting

Condition: Hearing Loss

Trial contact: 1-416-480-6100

More information: https://clinicaltrials.gov/study/NCT05129748

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

You are receiving cisplatin (a type of chemotherapy) as part of your cancer treatment
You are 18 years old or older
You are willing to sign a consent form agreeing to take part
You are reasonably well and able to carry out daily activities with little or no help (confirm with trial site)
If you could become pregnant, you have had a negative pregnancy test before starting the study treatment
If you are able to have children (male or female), you agree in writing to use reliable contraception for the entire duration of the trial

Who may not be able to join:

You are under 18 years old
You already have a significant hearing loss in one or both ears, as confirmed by a hearing test
You have a history of Meniere's disease or a condition that causes your hearing to change or fluctuate over time
You have a noticeable difference in hearing ability between your two ears (confirm with trial site)
Your kidneys are not working well enough (confirm with trial site)
Your liver is not functioning within acceptable levels, based on blood tests (confirm with trial site)
You have previously had an allergic reaction to STS (sodium thiosulfate) or mannitol
You are currently pregnant or breastfeeding
For any reason, you would not be able to follow the trial's requirements

⚠️ Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 23 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Phase 2

Sponsor

Sunnybrook Health Sciences Centre

Registry

ClinicalTrials.gov

Start date

15 February 2023

Est. completion

1 January 2027

Where this trial is recruiting

🇨🇦 Canada

Primary endpoints

Improvement in hearing threshold with sodium thiosulfate and mannitol administration

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov