Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have colorectal cancer that has spread to the liver, where the tumour is on the borderline of being removable by surgery, or currently cannot be safely removed because there is not enough healthy liver remaining — and where the surgical team believes surgery with a curative goal may still be possible
• People whose liver scans show that a procedure to redirect blood flow in the liver (called portal vein embolization, or PVE) would be needed to grow the healthy portion of the liver enough before a major liver surgery — either as a single operation or as part of a planned two-stage surgery
• People who have already received at least four cycles, or approximately two months, of chemotherapy
• People who are willing and mentally able to provide written consent to participate
• People who are considered medically and physically fit enough for surgery, as determined by their surgeon

Who may not be able to join:

• People who have cancer spread to areas outside the liver that would prevent the treatment plan from having a curative goal — though a treatable primary tumour and lung spread may still be allowed if a future plan for local treatment (such as surgery, radiation, or ablation) has been determined by the oncology team
• People whose healthy liver portion is projected to be too small to realistically reach the required level of improvement, even with treatment (confirm with trial site)
• People whose general physical functioning falls below a certain level, as measured by standard medical scoring tools (confirm with trial site)
• People who have high blood pressure in the liver's blood vessels (portal hypertension) or liver scarring (cirrhosis)
• People whose bilirubin blood level (a marker of liver function) is above a certain threshold before starting, unless they have a specific inherited condition called Gilbert's Disease
• People whose CEA blood marker (a tumour-related protein) remains above a certain level after four cycles of chemotherapy
• People whose cancer has clearly continued to grow or spread — based on scans or blood markers after four cycles of chemotherapy — and where the surgical and oncology teams have determined that surgery is no longer a viable option
• People with a platelet count (a blood clotting measure) below a certain level
• People with a low albumin level (a protein that reflects nutritional and liver health) in their blood
• People who still have an active, symptom-causing colon or rectal tumour that has not already been managed with a diverting stoma (a surgically created opening to redirect bowel waste)
• People who are pregnant or breastfeeding
• People who have other medical conditions that would make liver surgery unsafe
• People who do not speak English

Important: Always verify eligibility with the trial site directly before applying.