Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are currently in hospital, being discharged, or are outpatients who have had a recent heart attack or unstable chest pain (angina) meeting specific medical criteria, OR outpatients who have a diagnosis related to heart and blood vessel disease, kidney disease, stroke or mini-stroke, circulation problems in the legs or arteries, certain heart conditions (such as irregular heartbeat, heart failure, or valve disease), or at least one risk factor such as high blood pressure, diabetes, high cholesterol, obesity (BMI of 27 or above), a family history of heart disease or stroke before age 60, or being a male aged 55 or older or female aged 60 or older
• People who have smoked an average of at least a certain number of cigarettes per day (confirm exact number with trial site, as the source appears incomplete) over the past year
• People aged 18 years or older
• People who are strongly motivated to quit smoking, as measured by a specific motivation scale (scoring level 5 or above)
• People who are able to understand and give informed consent in English or French
• People who, if placed in the combination treatment group, are willing and able to purchase a specific type of e-cigarette: rechargeable, closed system with sealed cartridges or pods, tobacco flavour or no flavour only, and nicotine strength of 20 mg/ml (2%) or less
• People who are likely to be available for follow-up appointments over 52 weeks

Who may not be able to join:

• People who are pregnant or breastfeeding
• People who have used varenicline or bupropion (medicines to help quit smoking), any type of e-cigarette (with or without nicotine), or certain anti-craving medications in the 30 days before being assessed for the trial
• People who have used nicotine replacement therapy (such as patches, gum, or lozenges) in the 7 days before being assessed for the trial
• People who have used varenicline or e-cigarettes (with or without nicotine) for 14 or more days in a row at any point in the past year
• People who have previously had a serious bad reaction to varenicline or e-cigarettes
• People whose heart failure is rated at a severe level (NYHA or Killip Class III or IV) at the time of joining the trial (confirm with trial site)
• People with any unstable mental health condition, as determined by the enrolling doctor
• People with significant kidney problems, specifically creatinine levels at twice or more the normal upper limit, or a kidney function score (eGFR) of 15 or below
• People who have used any illegal drugs in the past year
• People who plan to smoke cannabis or use any other smoked or smokeless tobacco products during the study period (note: non-smoked cannabis products such as edibles or oils are permitted)

Important: Always verify eligibility with the trial site directly before applying.