Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged over 18 years old
• People whose general health and ability to carry out daily activities meets a certain standard (a medical scoring system called ECOG gives a score of less than 2, meaning the person is reasonably active — confirm with trial site)
• People who have been diagnosed with intrahepatic cholangiocarcinoma (a type of bile duct cancer that starts inside the liver), confirmed by laboratory analysis of tissue
• People who have not received any previous treatment for this type of cancer
• People whose tumour has been assessed by a liver and bile duct specialist surgeon, and confirmed by a surgical review board, as able to be surgically removed
• People whose cancer falls into at least one higher-risk category: the surgeon expects the surgical margin (the gap between the tumour and the cut edge) to be less than 1 cm; or the tumour is larger than 5 cm; or there are multiple tumours that have been confirmed as removable by a surgical review board
• People who are registered with a social security scheme
• People who have been given full information about the trial and have signed a consent form (or whose legal representative has done so)

Who may not be able to join:

• People with severe liver scarring (advanced fibrosis or cirrhosis)
• People whose blood test results show that the blood, liver, kidney, or clotting functions are below the required levels (specific thresholds apply — confirm with trial site)
• People with a higher-than-accepted level of a substance called uracil in the blood (above 16 ng/mL)
• People with serious breathing difficulties
• People with other serious health conditions, such as severe heart disease, that would make surgery unsafe
• People for whom a large portion of the liver is planned to be removed, and who have significant fat accumulation in liver cells (above 60%) or a specific liver condition called regenerative nodular hyperplasia
• People for whom threading a tube into the liver's artery is not possible due to blood vessel abnormalities or bleeding problems
• People who have previously received chemotherapy, including for a different cancer
• People who have previously received radiotherapy to the upper abdomen, including for a different cancer
• People who currently have another active cancer
• People who are already taking part in another interventional clinical trial testing a medical treatment before surgery
• People who are pregnant, likely to be pregnant, or breastfeeding; or people of reproductive age (male or female) who are not using effective contraception from the screening stage until 30 days after the end of treatment
• People who are minors, people who are legally restricted in their freedoms, or people under any form of legal guardianship
• People who, for social, medical, or psychological reasons, would not be able to attend the required medical follow-up for the trial
• People in whom preliminary imaging shows that too much radiation would reach the lungs during a planned procedure (lung dose above 30 Gy — confirm with trial site)
• People in whom a shunt (abnormal diversion of blood flow) toward the digestive system is found and cannot be corrected by a minimally invasive procedure
• People in whom a pre-procedure scan shows that the targeted substance does not accumulate in the tumour as needed

Important: Always verify eligibility with the trial site directly before applying.