Phase 3 Type 2 Diabetes Trial, Recruiting NCT05345327 Sponsor: The George Institute Condition: Type 2 Diabetes
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Phase 3 Type 2 Diabetes Trial, Recruiting

NCT05345327
Recruiting Phase 3 🇦🇺 Australian site

voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice

Who may and may not be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who may be able to join

  • People who have been diagnosed with type 2 diabetes
  • People who are 18 years of age or older
  • People with a body mass index (a measure of body weight relative to height) above 18.5
  • People who are either not currently taking any diabetes medication, or who are only taking metformin, and who are willing to be randomly assigned to take either dapagliflozin or metformin as part of the trial
  • People whose kidneys are working at a sufficient level (a kidney function score of 45 or above on a standard test called eGFR)
  • People who have given their written agreement to participate in the trial

Who may not be able to join

Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.

  • People whose blood sugar levels are so high that their doctor feels they urgently need stronger diabetes treatment right away
  • People for whom either metformin or a type of medication called an SGLT2 inhibitor is either clearly recommended as necessary or clearly not safe to take
  • People who have a confirmed history of serious heart conditions, such as a heart attack, a procedure to open blocked heart arteries, heart bypass surgery, or heart failure that has been diagnosed by a hospital admission, a specialist, or a heart scan
  • People who are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 31 July 2026

Contact this trial

Principal Investigator: Bruce Neal, The George Institute for Global Health (Sydney, Australia)

Phone: +61 2 8052 4337

Australian sites

The George Institute for Global Health, Sydney, New South Wales
+61 2 8052 4337
The George Institute for Global Health, Brisbane, Queensland
+61 2 8052 4337
Monash University, Melbourne, Victoria

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
The George Institute
Registry
ClinicalTrials.gov
Start date
1 January 2023
Est. completion
30 June 2026

This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.

Where this trial is recruiting

🇦🇺 Australia Sri Lanka

3 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Rate of decline in eGFR

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 31 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov