Cardiomyopathy Trial, Recruiting NCT05427370 Sponsor: Sunnybrook Health Sciences Centre Condition: Cardiomyopathy
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Cardiomyopathy Trial, Recruiting

NCT05427370
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are over 18 years old
  • Your heart's pumping function is measured at 40% or less (called an "ejection fraction"), confirmed by a heart scan within the past 2 months
  • You have significant blockages in multiple heart arteries — specifically in three vessels, or in two vessels including a major one (confirm with trial site for exact details on how blockage is measured)
  • You have been on recommended heart medications for at least 1 month, or your medical team has started you on these medications and plans to continue them after any procedure
  • You have given written consent to take part in the trial

Who may not be able to join:

  • You needed emergency support for heart failure (such as a breathing machine, heart pump, or strong heart medications) in the 48 hours before joining the trial
  • You had a certain type of serious heart attack (ST-elevation MI) within the past 4 weeks
  • You have a severe heart valve problem or another heart condition that requires surgery to repair
  • You are already scheduled for another major surgery at the same time (some smaller procedures may still be allowed — confirm with trial site)
  • You had a heart artery procedure (stent/angioplasty) within the past 12 months
  • You have previously had open heart surgery
  • You have a very high risk of serious bleeding that means you cannot safely take two blood-thinning medications together
  • There are concerns that you may have difficulty following the treatment plan
  • You have a serious illness affecting another major organ (such as kidney failure requiring dialysis, liver failure, lung failure, or cancer) that is expected to reduce your life expectancy to less than 5 years
  • You are currently pregnant
  • Your medical team does not consider you suitable for either type of heart procedure being studied in this trial (confirm with trial site)
  • Your reduced heart function is caused by a temporary stress-related condition sometimes called "Broken Heart Syndrome"

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Stephen Fremes, MD,MSc,FRCSC, Sunnybrook Health Sciences Center, Toronto, Canada

Phone: 416-480-6100

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
22 June 2023
Est. completion
1 April 2029

Where this trial is recruiting

🇦🇹 Austria 🇧🇷 Brazil 🇨🇦 Canada 🇨🇳 China 🇭🇷 Croatia 🇪🇬 Egypt 🇩🇪 Germany 🇮🇳 India 🇮🇹 Italy 🇲🇽 Mexico 🇵🇱 Poland 🇵🇹 Portugal 🇷🇸 Serbia 🇪🇸 Spain 🇺🇸 United States

Primary endpoints

The Primary outcome is a Composite of all-cause mortality, stroke, spontaneous myocardial infarction, urgent repeat revascularization or heart failure readmission.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov