Phase 2 HIV and AIDS Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial (recipients/patients):

• People who have a blood cancer that has been confirmed by laboratory testing and that doctors consider appropriate for a stem cell transplant from a related donor, including certain types of leukemia, lymphoma, myeloma, or related blood conditions (confirm with trial site for your specific diagnosis and whether your disease is at the right stage)
• People living with HIV whose HIV levels are kept very low (under 400 copies/mL) by a stable anti-HIV medication regimen, and whose medication regimen meets specific requirements depending on which dose group they are assigned to
• People aged 18 or older
• People who have at least one close biological relative (such as a parent, child, or sibling) who is a partial tissue-type match and willing to donate
• People with a general health and activity level rated at 50% or above on a standard medical scale (meaning able to care for themselves, though may need occasional help)
• People whose heart is pumping adequately (at least 40% efficiency on an ultrasound test)
• People whose lungs are functioning adequately (meeting minimum thresholds on breathing tests, or showing no breathing problems at rest if testing is not possible)
• People whose liver is functioning adequately, based on specific blood test results being within acceptable ranges
• People whose kidneys are filtering at an adequate rate, based on a standard blood test
• People who are able to understand the study and are willing to sign a consent form
• People of childbearing potential, or those who can father children, who agree to use reliable contraception before joining and for at least one year after the transplant

Who may not be able to join (recipients/patients):

• People currently taking part in another experimental treatment study, unless that treatment can be stopped or completed at least two weeks before the conditioning process begins
• People whose blood cancer is not well enough controlled — for example, leukemia that has not reached remission, lymphoma that has not responded to treatment, or myeloma that has not reached complete remission
• People with a serious ongoing illness that, in the lead doctor's opinion, would make a transplant unsafe
• People for whom the study team cannot find a suitable anti-HIV medication plan that keeps the HIV virus sufficiently suppressed and is compatible with the study drugs
• People who are currently pregnant
• People who are breastfeeding and are not willing to stop before treatment begins on day 14 of the study schedule
• People with a serious allergy to any of the medications used in this study (including certain immune-suppressing drugs, chemotherapy agents, and other study medications)
• People for whom a central intravenous line (a type of tube placed in a large vein, needed for transplant) cannot be safely placed
• People with an active psychiatric condition that the lead doctor believes would significantly affect their ability to follow the transplant plan and HIV medication schedule
• People with severe nerve damage affecting movement or sensation (grade 3–4 on a standard medical scale)

Who might be able to join this trial (related donors):

• Related donors aged 12 or older who are considered medically suitable and willing to donate, following the transplant centre's standard evaluation process, and who are also willing to provide blood and/or stem cell samples for research purposes
• People (or their parent or legal guardian, if applicable) who are able to understand the study and are willing to sign a consent form

Who may not be able to join (related donors):

• People who do not meet the transplant centre's standard requirements for donors

Important: Always verify eligibility with the trial site directly before applying.