Depression and Anxiety Trial, By Invitation
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are male or female and between 18 and 60 years old.
- People who have been diagnosed with Major Depressive Disorder (MDD).
- People who show depressive symptoms as measured by one of three standard questionnaires (PHQ-9, HDRS, or SHAPS).
- People who are able to understand, agree to, and sign a consent form, and are willing to complete all study procedures.
- Female participants who are not pregnant and not breastfeeding at the time of the brain scans and treatment sessions.
- People who have no medical reasons preventing them from having an MRI scan (for example, no pacemaker, cochlear implants, metal in the eyes, or other metal implants), and who pass the pre-screening MRI questions from the imaging centre.
- People who have no medical reasons preventing them from receiving TMS (a type of brain stimulation), such as no non-removable metal in the head (outside the mouth) or within 12 inches of the treatment device, and who pass the TMS safety screening questionnaire.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who, in the opinion of the clinical or research team, are unlikely to complete the study because they are not able to tolerate TMS treatment.
- People who are unable to understand the study design and what taking part involves.
- People who are unable to sign the consent form for any reason.
- People who have an unstable medical condition, including HIV/AIDS, active hepatitis, active tuberculosis, unstable heart disease, unstable diabetes, or significant liver or kidney problems.
- Female participants who are pregnant or breastfeeding.
- People who have medical reasons preventing them from having an MRI scan (for example, a pacemaker, cochlear implants, metal in the eyes, or other metal implants), or who do not pass the imaging centre's pre-screening MRI questions.
- People who have medical reasons preventing them from receiving TMS, such as non-removable metal in the head (outside the mouth) or within 12 inches of the treatment device, or who do not pass the TMS safety screening questionnaire; additional safety guidelines from an international expert panel on brain stimulation also apply (confirm with trial site).
- People who do not speak English, as the study team does not currently have the resources to support other languages.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
Functional connectivity of orbital frontal cortex (OFC); Outcome Changes in MDD subjects
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.