Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are over 18 years of age
• People who have had ongoing chest pain (angina) symptoms rated as moderate to severe for at least 3 months, even while taking at least two anti-anginal (chest pain) medicines at the highest doses they can tolerate
• People who are willing to keep their current chest pain medicines unchanged for the entire duration of the trial
• People whose heart arteries do not have significant blockages (no more than 50% narrowing), as confirmed by a heart artery imaging test (coronary angiography)
• People whose heart scan (a type of MRI called CMR) shows reduced blood flow to the heart muscle during stress testing, based on a specific measurement (confirm with trial site)
• People who are willing to attend all required follow-up appointments and remain contactable throughout the trial
• People who understand what the trial involves and have signed a written consent form

Who may not be able to join:

• People who have significant blockages in a main heart artery (more than 50% narrowing, or abnormal pressure measurements), have had heart bypass surgery, or have had a heart attack
• People who have had a heart artery procedure (PCI) within the past 6 months
• People who have previously had a stent placed during a heart attack or to open a completely blocked artery
• People with an unusual shape or structure of the coronary sinus (a vein near the heart) — including unusual bends, extra branches, or an abnormal vein on the left side of the chest
• People whose coronary sinus is too narrow (under 9.5mm) or too wide (over 13mm) at the location where a device would be placed
• People whose right atrium (a heart chamber) has a pressure measurement below a certain level at the time of the procedure (confirm with trial site)
• People with certain structural heart conditions, including an enlarged heart muscle, heart muscle disease, severe heart valve disease, a previous heart valve replacement, a muscular band pressing on a heart artery, or reduced pumping function of the heart (less than 45% by heart MRI)
• People who have been diagnosed with coronary vasospasm (sudden tightening of the heart arteries), either by symptoms or by imaging
• People who have previously been hospitalised for severe heart failure
• People who have a pacemaker or defibrillator lead (wire) located in the right side of the heart or the coronary sinus
• People who have a documented irregular heart rhythm that means a permanent pacemaker or defibrillator is planned
• People with significant kidney disease (based on blood test results, being on dialysis, or having a kidney transplant)
• People with a low red blood cell level (haemoglobin below 80g/L)
• People who cannot take a specific type of blood-thinning medicine combination (dual antiplatelet therapy)
• People with severe chronic lung disease, based on breathing test results
• People who are very unwell and are not expected to live longer than one year
• People with a known allergy to nickel or steel
• People who are currently taking part in another clinical trial of an investigational device or drug
• People who cannot safely have a heart MRI scan or receive a specific medicine used during the scan (adenosine)
• People who are pregnant

Important: Always verify eligibility with the trial site directly before applying.