Phase 2 HIV and AIDS Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 21 and 70 years old
• People who are able to understand and agree to take part in a series of brain and medical assessments
• People who have used cannabis at least once in the past 5 years without serious negative reactions (such as psychosis or fainting)
• People who have used cannabis very little or not at all in the past 2 weeks — meaning either no use, or no more than one time in that period
• People who are willing to avoid cannabis, CBD, THC, and synthetic cannabinoids outside of the study for the full 6-week study period
• People who are able to attend all required study visits
• People living with HIV may be considered if they meet all of the following additional conditions: their HIV virus levels are undetectable and they have been on a stable HIV treatment (ART) regimen for at least 6 months with no more than one past treatment change due to the virus becoming resistant; their HIV is classified as Stage 1 or 2; their immune cell count (CD4) is at or above 350 cells per microlitre; and they have not had significant difficulty sticking to their HIV medication regimen

Who may not be able to join:

• People who have had a substance use disorder (other than cannabis) in the past 30 days
• People with significant memory or thinking problems, such as dementia or Alzheimer's disease
• People who are pregnant, breastfeeding, or unwilling to use reliable contraception during the trial (for people who could become pregnant, or whose partner could become pregnant)
• People with moderate or severe liver or kidney problems, including certain abnormal liver test results (confirm with trial site)
• People with significant heart health concerns, including a resting heart rate below 50 or above 110 beats per minute, poorly controlled blood pressure, or a history of heart attack, heart failure, or irregular heart rhythms
• People with a chronic lung condition that requires supplemental oxygen
• People with a history of liver or bile duct illness, or certain abnormal liver test results detected at screening (confirm with trial site)
• People who require insulin to manage diabetes
• People with a known allergy to the study drugs or their ingredients, including sesame
• People taking medications that are known to interact with the study drugs (confirm with trial site)
• People taking medications that cause sedation
• People who weigh less than 60 kg at the time of screening
• People with an active and uncontrolled psychiatric condition involving psychotic features, severe depression, or suicidal thoughts or behaviour — including a history of suicide attempts, or a score of 29 or higher on a standard depression questionnaire (BDI-II)
• People with a neurological condition that could affect the study results, such as uncontrolled seizures in the past 3 months, multiple sclerosis, Parkinson's disease, Alzheimer's disease, or a recent stroke or brain bleed with lasting neurological effects

Important: Always verify eligibility with the trial site directly before applying.