Phase 4 HIV and AIDS Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults between 18 and 75 years old, of any gender
- People living with HIV whose virus levels in the blood have stayed below 1,000 copies/ml for the past 12 months
- People who have been diagnosed with nerve-related pain (such as painful nerve damage, radiating pain, complex regional pain syndrome, or nerve pain after spine surgery), confirmed using a specific pain screening tool used in this study
- People whose pain levels average more than 4 out of 10 and have lasted longer than 3 months
- People who are able to understand and agree to the study requirements
- People who speak fluent English
Who may not be able to join:
- People with a known allergy to the medication naltrexone (this does not apply to the control group)
- People who have used opioid medications within the 10 days before the study starts (this does not apply to the control group)
- People who are currently pregnant
- People who are breastfeeding, or people of childbearing potential who are not using two highly effective forms of contraception throughout the 12-week study — acceptable methods include hormonal contraception, an intrauterine device (IUD/IUS), barrier methods with spermicide, total abstinence, or sterilisation (this does not apply to the control group)
- People with a diagnosis of bipolar disorder, schizophrenia, or poorly controlled anxiety or depression
- People with a diagnosis of liver disease, such as cirrhosis
- People with chronic or acute kidney disease, or whose kidney function falls below a certain level at the start of the study (confirm with trial site)
- People with an active hepatitis A, B, or C infection
- People who have recently tested positive for COVID-19 or been diagnosed with another viral illness within the past 10 days
- People with a known or suspected diagnosis of long COVID
- People with an active drug or alcohol use disorder
- People who are likely to need opioid medications during the study period, for example due to planned surgery
- People who have transport difficulties that would prevent them from attending follow-up study visits (this does not apply to the control group)
- People who are not able to provide informed consent
- People who are currently imprisoned
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Anne M McKenzie-Brown, MD, Emory University
Phone: 404-686-2410
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Changes in Numerical Pain Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 12 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.