Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 85 years old.
• You have been diagnosed with a type of irregular heartbeat called paroxysmal atrial fibrillation, confirmed by a heart tracing (ECG), and your symptoms started less than 48 hours before arriving at the Emergency Department.
• Alternatively, your irregular heartbeat started between 48 hours and 7 days before arriving at the Emergency Department, and you have been taking blood thinners for at least 30 days.
• Alternatively, you have a history of coronary artery disease (blocked or narrowed heart arteries) without any ongoing reduced blood flow to the heart, confirmed by one of the following: a heart procedure (PCI) within the last year, bypass surgery (CABG) within the last 3 years, or a normal stress imaging test within the last year combined with a history of significant artery narrowing or older heart procedures (confirm with trial site).
• Your heart is pumping with at least 35% of its normal strength, confirmed by a heart ultrasound done at the Emergency Department or within the past year.
• You or your legal representative are willing and able to sign a consent form agreeing to take part.

Who may not be able to join:

• Your ECG at the Emergency Department shows a different type of heart rhythm problem called atrial flutter.
• Your ECG shows a newly found electrical conduction problem in your heart called Left Bundle Branch Block (LBBB).
• Your ECG shows a newly found Right Bundle Branch Block (RBBB) with a specific electrical delay measurement over 150ms (confirm with trial site).
• A previous 24-hour heart monitor recording showed a high number of irregular heartbeats (more than 720 extra beats in 24 hours) or episodes of a fast, dangerous heart rhythm (confirm with trial site).
• You have no history of coronary artery disease (blocked or narrowed heart arteries).
• You are having a major heart attack with a specific pattern on your ECG (called STEMI).
• You are having a type of heart attack without that specific ECG pattern (called NSTEMI), based on blood test results measured at the Emergency Department (confirm with trial site).
• You are experiencing chest pain caused by reduced blood flow to the heart at rest or with very little activity, without signs of a heart attack (confirm with trial site).
• You have known ongoing reduced blood flow to the heart, confirmed by a positive stress imaging test or an older normal stress test combined with a history of significant artery narrowing or older heart procedures (confirm with trial site).
• You have had any type of heart attack or serious cardiac event within the past year.
• You have severe narrowing of the heart's aortic valve, confirmed by specific measurements (confirm with trial site).
• You have severe kidney disease (stage 4 or higher).
• You have a serious ongoing illness, including cancer currently being treated, liver failure, or an active infection with fever.
• You took a heart medication called flecainide or propafenone as a one-off dose to try to correct your heart rhythm within 6 hours before coming to the Emergency Department.
• You have a known sensitivity or allergic reaction to flecainide or amiodarone (two heart medications).
• You are pregnant or breastfeeding.
• You are currently taking part in another clinical trial.
• Your life expectancy is less than one year.
• You are unable, unwilling, or considered unsuitable to follow the procedures required by this trial.

Important: Always verify eligibility with the trial site directly before applying.