Sleep Disorders Trial, Recruiting NCT05551325 Sponsor: Yale University Condition: Sleep Disorders
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Sleep Disorders Trial, Recruiting

NCT05551325
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years old or older
  • You are seriously ill and admitted to the Medical Intensive Care Unit (MICU) and need a breathing machine, breathing support through a mask or high-flow oxygen through the nose, or medications to support your blood pressure
  • You were admitted to the hospital within 24 hours before entering the MICU, and the study would begin on the second or third day of your MICU stay
  • You are still on the qualifying breathing or blood pressure support at 9:00 AM on the day you would be enrolled in the study

Who may not be able to join:

  • You are not expected to stay in the MICU for at least 48 hours after being enrolled in the study
  • You are considered to be at the very end of life or receiving hospice care
  • You have a severe long-term brain injury (more than 30 days ago) that prevents you from living independently
  • You have any level of recent brain injury that could affect the part of the brain that controls your body clock — for example, a cardiac arrest (confirm with trial site)
  • You have a diagnosed sleep/body clock disorder, or you are blind or have a disease of the optic nerve
  • You have worked night shifts or rotating shifts in the past year
  • You are currently or were recently homeless, in prison, or living in an institution
  • You are at higher risk of inhaling food into your lungs due to a stomach or digestive problem, or you were receiving tube feeding before entering the ICU
  • You were admitted to the ICU for a serious diabetes-related emergency (diabetic ketoacidosis or hyperosmolar state)
  • You have a history of low blood sugar (hypoglycemia) without a documented full recovery
  • You have a medical history suggesting an unusually high risk of low blood sugar, such as a known insulin-producing tumor, repeated unexplained episodes of low blood sugar, or severe liver failure
  • You were admitted due to a suicide attempt
  • You were admitted due to a drug overdose or are going through active alcohol withdrawal
  • You have tested positive for SARS-CoV (the virus related to COVID-19)
  • For a specific urine test part of the study only: you have or have tested positive for HIV, West Nile virus, Monkeypox, or tuberculosis (TB)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 2 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

GP referral letter

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Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Registry
ClinicalTrials.gov
Start date
13 May 2024
Est. completion
29 June 2029

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Circadian alignment based on diurnal heart rate variation

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov