Phase 4 Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People (men and women) who have previously had a procedure to open or bypass blocked heart arteries, OR who have been found on heart imaging to have significant blockages in major heart arteries.
- People who are scheduled for a type of surgery considered to carry an intermediate or high risk to the heart — such as abdominal, brain, chest, or major vascular surgery.
- People scheduled for only a minimally invasive or keyhole-type surgical approach may also be eligible if at least one of the following is also present: a past heart attack, a history of heart failure, a past stroke or mini-stroke, use of insulin before surgery, or a certain level of reduced kidney function before surgery (confirm with trial site).
Who may not be able to join:
- People who have used the medication colchicine within the past month, or who have had a bad reaction to colchicine in the past.
- People who have inflammatory bowel disease with a history of diarrhoea as a symptom, or who experience ongoing chronic diarrhoea.
- People who have a pre-existing and progressing neuromuscular disease, such as ALS (motor neurone disease), inherited muscle disorders, muscle inflammation conditions, myasthenia gravis, or Lambert-Eaton syndrome.
- People whose kidneys are functioning at a low level (filtration rate below 30 mL/minute) or who are on dialysis.
- People with a history of cirrhosis, long-term active hepatitis, or serious liver disease.
- People with a history of a blood disorder called myelodysplasia who currently show signs of low blood cell counts.
- People who have an active infection at the time of enrolment, indicated by fever, abnormal white blood cell counts, or current antibiotic use.
- People who are currently receiving chemotherapy or biological treatments that affect the immune system.
- People who are pregnant, breastfeeding, or planning to become pregnant during the study period.
- People who are already participating in another competing research study, or who are not able to give their own consent to participate.
- People with any other significant health condition that the trial team determines could increase risk, interfere with results, or make it difficult to follow the study procedures (confirm with trial site).
- People who are currently taking certain medications that can interact with the study drug — specifically strong inhibitors of CYP3A4 or P-glycoprotein, such as ritonavir, clarithromycin, diltiazem, or verapamil. Participants will also be asked to avoid grapefruit juice while taking the study drug.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Binita Shah, MD, VA NY Harbor Healthcare System, New York, NY
Phone: (718) 836-6600
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Major adverse cardiovascular events
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.