Heart Disease Trial, Recruiting NCT05696522 Sponsor: Barts & The London NHS Trust Condition: Heart Disease
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Heart Disease Trial, Recruiting

NCT05696522
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged between 18 and 85 years old.
  • People who have had at least three episodes of a dangerous fast heart rhythm called ventricular tachycardia (VT) in the past six months, where their implanted heart device (ICD) had to deliver treatment to stop it.
  • People whose VT has not been controlled by the highest tolerated doses of heart rhythm medications and/or a standard procedure to treat the abnormal rhythm (called catheter ablation).
  • People who are either too unwell to undergo standard catheter ablation, or who do not wish to have it.
  • People who have not previously had radiotherapy to the area of the body that would be treated in this trial.

Who may not be able to join:

  • People who have a type of irregular heart rhythm called polymorphic VT or ventricular fibrillation (VF), rather than the specific type this trial targets.
  • People whose heart failure is so severe that it requires continuous medication to keep the heart pumping, or who have a mechanical heart pump device (LVAD) already in place.
  • People whose overall health means they are not expected to live more than 12 months, regardless of their heart rhythm condition.
  • People whose VT may have a treatable underlying cause, such as a significant blockage in the heart's arteries or a hormonal or metabolic condition like an overactive thyroid.
  • People who are not able to give their own informed consent to participate in the trial.
  • People who have previously had radiotherapy to the area of the body that would be treated in this trial.
  • People who weigh more than 170kg, due to the maximum weight limit of the imaging equipment used in the trial.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 13 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 020 37658635

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Barts & The London NHS Trust
Registry
ClinicalTrials.gov
Start date
12 January 2023
Est. completion
2 May 2026

Where this trial is recruiting

🇬🇧 United Kingdom

Primary endpoints

Change in quality of life and cardiac complications as assessed by clinical history, SF-36 questionnaire, electrocardiogram and echocardiography.; Efficacy endpoint - Cumulative VT burden 6 months before and 6 months after radiotherapy.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov