Phase 1 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been clinically diagnosed with heart failure
• People whose doctors have no plans to change or adjust their heart failure medications or devices during the study period
• People who have not had an unplanned hospital stay in the past 2 weeks
• People whose fluid levels are considered stable and well-managed by their medical team
• People whose blood potassium level is 5.0 mmol/L or below
• People whose blood sodium level is 130 mEq/L or above
• People who are older than 18 years of age
• People whose haemoglobin (a measure of red blood cells) is 8 g/dL or above
• People whose test results show that their body is not responding well enough to a standard water tablet (diuretic) challenge, based on specific measurements of sodium in the urine and other kidney function indicators (confirm with trial site)

Who may not be able to join:

• People whose kidneys are functioning at a very low level (confirm with trial site) or who are on dialysis or another form of kidney replacement therapy
• People who have taken certain types of water tablets (non-loop diuretics) in the last 7 days or so, with some exceptions for low-dose medications — the trial site can clarify which medications are affected
• People with a history of sudden severe fluid build-up in the lungs requiring hospitalisation and breathing support, or people with a heart condition that makes their fluid balance particularly fragile, such as amyloid cardiomyopathy
• People whose haemoglobin is below 8 g/dL or who have anaemia causing symptoms
• People who are pregnant or breastfeeding
• People who are unable to provide written informed consent or who would have difficulty following the study's procedures and appointments
• People who have a chronic urinary retention condition that would make timed urine collection difficult
• People currently taking lithium
• People currently taking pimozide or thioridazine
• People who have been diagnosed with liver failure
• People who have an allergy or medical reason to avoid sulfonamide-type medications
• People who have an allergy or medical reason to avoid thiazide diuretics or the specific medication bendroflumethiazide

Important: Always verify eligibility with the trial site directly before applying.