Heart Disease Trial, Recruiting NCT05756608 Sponsor: University of Edinburgh Condition: Heart Disease
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Heart Disease Trial, Recruiting

NCT05756608
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

Group 1 – Aortic Stenosis (a narrowing of a heart valve):

  • You are male or female and aged 50 or older
  • You have been diagnosed with severe, moderate, or mild aortic stenosis (a narrowing of the main heart valve), or a thickened but not blocked aortic valve
  • You are willing and able to give your consent to take part before any study procedures begin
  • Healthy volunteers aged 50 or older with no major health conditions may also be eligible (as decided by the lead researcher)

Group 2 – Heart damage caused by chemotherapy:

  • You are male or female, aged 35 or older, and have shown signs of heart damage on a cardiac MRI at least 1 year after receiving a type of chemotherapy called anthracyclines
  • You are aged 35 or older and had anthracycline chemotherapy but showed no signs of scarring on your 1-year heart scan
  • Healthy volunteers aged 35 or older with no major health conditions may also be eligible (as decided by the lead researcher)
  • You are willing and able to give your consent before any study procedures begin

Group 3 – Carcinoid syndrome (a condition caused by a type of slow-growing tumour):

  • You are male or female, aged 35 or older, and have been diagnosed with carcinoid syndrome (with or without heart involvement), diagnosed according to agreed medical guidelines
  • You are willing and able to give your consent before any study procedures begin

Who may not be able to join:

  • You are unable or unwilling to give your consent to take part
  • You have claustrophobia (fear of enclosed spaces) or feel you would be unable to lie still on your back for an MRI scan
  • Your kidneys are not working well enough (confirm with trial site for specific kidney function levels)
  • You are currently pregnant or breastfeeding
  • You have a known allergy to contrast dye (a substance sometimes used during scans)
  • You have a metal implant or another reason why you cannot safely have a cardiac MRI scan
  • You have recently had a heart attack, or have another known cause of heart muscle disease or heart scarring

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Marc Dweck, MBBS PhD, University of Edinburgh

Phone: 07774365798

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
University of Edinburgh
Registry
ClinicalTrials.gov
Start date
10 November 2022
Est. completion
31 August 2028

Where this trial is recruiting

🇬🇧 United Kingdom

Primary endpoints

Fibrosis activity: Standardised uptake values (SUV; Fibrosis activity:Tissue-to-Background Ratio

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov