Cardiomyopathy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults between 18 and 80 years old who have been diagnosed with hypertrophic cardiomyopathy (a condition where the heart muscle is thicker than normal), confirmed by a specific heart ultrasound measurement or by other supporting signs such as a family history of the condition or a positive genetic test.
- People whose heart's main outflow passage does not show significant blockage, both at rest and during physical activity (as measured during testing).
- People whose heart is pumping at least 50% of its blood volume with each beat, as measured by a specific ultrasound method.
- People who have access to exercise equipment, either at home or at a gym or fitness centre.
- People who are able to complete online surveys and use a smartphone as part of the study requirements.
- People who are able to participate in 24 weeks of exercise training.
Who may not be able to join:
- People who have a history of fainting or dangerous heart rhythm problems triggered by exercise.
- People who are currently being assessed for a procedure to reduce blockage in the heart's outflow passage, or who are fewer than 3 months past such an assessment.
- People who have previously had a surgical or catheter-based procedure to reduce thickening of the heart wall.
- People who have had a heart device (implantable defibrillator) placed within the past 3 months.
- People who have shown a significant drop in blood pressure during exercise testing (a drop of more than 20 mmHg from their starting blood pressure).
- People who have had a serious worsening of their heart condition in the past 3 months, including severe heart failure symptoms or severe chest pain symptoms at rest or with minimal activity.
- People whose heart is pumping less than 50% of its blood volume with each beat, as measured by heart ultrasound.
- People whose life expectancy is less than 12 months.
- People who are pregnant or planning to become pregnant.
- People who are unable to exercise due to any medical or other reason.
- People who are unwilling to avoid competitive sports, sudden bursts of intense activity, or heavy resistance-type exercise for the duration of the study, if assigned to the non-exercise group.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Theodore P Abraham, M.D, University of California, San Francisco
Phone: 415-514-1125
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in V O2 max; Change in peak VO2 %
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.