Phase 4 Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have nasal polyps in both nostrils, confirmed by a nasal camera examination (endoscopy) or a CT scan
• You have had at least one surgery for nasal polyps in the last 10 years
• Your nasal polyp symptoms are severe enough that surgery is being considered, based on specific symptom and examination scores (confirm with trial site)
• You have been using a steroid nasal spray or nasal rinse/wash consistently for at least 4 weeks before the screening appointment
• You have had at least 2 of the following symptoms for at least 12 weeks: blocked or congested nose, nasal discharge or post-nasal drip, facial pain or pressure, reduced or lost sense of smell

Who may not be able to join:

• The doctor responsible for the trial considers you unfit to participate based on your medical history, physical examination, or screening tests
• You have cystic fibrosis
• You have certain specific conditions affecting your airways or the tiny hair-like structures in your nose, including Churg-Strauss syndrome, Young's syndrome, or Kartagener's syndrome (confirm with trial site)
• Your nasal polyps are a specific type called antrochoanal polyps
• Your nasal wall (septum) is so deviated that it completely blocks one nostril
• You have an active sinus infection or upper respiratory infection, or had one within 2 weeks before your screening appointment
• You are experiencing a type of ongoing congestion caused by overuse of nasal decongestant sprays
• You have had any nasal or sinus surgery (such as polyp removal or balloon dilation) in the 6 months before joining the trial
• Your doctor feels that nasal polyp surgery would not be safe for you
• You have a known history of HIV infection
• You have had a parasitic infection within the 6 months before joining the trial
• You are currently receiving, or have received within the last 3 months (or longer, depending on the medication), radiotherapy or an experimental medication or treatment
• You have a known allergy or sensitivity to any of the study medications or their ingredients — though participants who are sensitive to aspirin may still be eligible
• You have previously had an allergic reaction to a type of medication called an anti-IL-5 treatment or any other monoclonal antibody therapy
• You have used steroid tablets or other systemic steroids within the 4 weeks before screening, or plan to use them during the trial
• You have used certain biological or immune-suppressing treatments (other than Xolair/omalizumab) within a specific time period before joining (confirm exact timeframe with trial site)
• You have used the medication omalizumab (Xolair) in the 130 days before joining the trial
• You have recently started or changed the dose of allergy immunotherapy (allergy shots or similar) within the past 3 months
• You are pregnant, breastfeeding, or planning to become pregnant during the study — effective contraception will be required for women who could become pregnant
• Your immune system is weakened due to a disease or medication (other than oral steroids)

Important: Always verify eligibility with the trial site directly before applying.