Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are at least 18 years old
• You have been diagnosed with liver cancer (HCC) confirmed by a tissue sample or by standard European liver disease guidelines
• Your tumor(s) are smaller than 5 cm, and the total of your largest tumor's size (in cm) plus the number of tumors you have adds up to 7 or less
• Your liver cancer is at an early or intermediate stage (BCLC Stage A or B) and curative treatment is not currently an option for you
• Your cancer has come back or your previous surgery or ablation treatment did not fully work — this is allowed, unless the cancer has returned in the exact area where a heat-based (thermal) ablation was previously done
• You are generally active and able to carry out daily activities with little or no limitation (performance status 0 or 1)
• Your cancer can be treated in a single session at the start of the trial
• Your liver is either healthy or has stable, well-controlled scarring (cirrhosis) with good liver function (Child-Pugh Class A)
• Your bilirubin level (a liver marker in your blood) is within an acceptable range
• Your blood counts — including red blood cells, white blood cells, and platelets — meet the minimum required levels
• You have no fluid build-up in your abdomen, or only a small amount that is managed by reducing salt in your diet (not by water tablets or drainage procedures)
• Your kidneys are working well enough as shown by blood test results
• You are willing and able to sign a consent form agreeing to take part
• If you are able to have children, you agree to use reliable contraception throughout the study and during follow-up

Who may not be able to join:

• You have previously had any systemic (whole-body) drug treatment for your liver cancer
• You have previously had any treatment delivered directly into the arteries of your liver (intra-arterial therapy) for liver cancer
• You are currently eligible for a curative treatment for your liver cancer
• Your cancer has returned in the same area where a previous heat-based (thermal) ablation was performed
• Your liver disease is at an advanced stage, or you have had internal bleeding from your digestive system or confusion caused by liver failure
• Your liver cancer is at an advanced stage (BCLC Class C or D), has spread into blood vessels or outside the liver, or is causing significant symptoms
• You have a history of another type of cancer, unless it was fully treated at least 5 years ago with no signs of it returning, or it occurred more recently but is not active and is not expected to come back or cause problems within the next 5 years
• You have a history of bile duct disease or blockage
• You have blood clots in the portal vein, abnormal blood flow patterns in your liver, or absent blood flow in the part of the liver being treated
• You are unable to have CT or MRI scans with contrast dye — for example, due to an allergy to contrast materials
• You have any other medical reason that would prevent you from safely having the embolization procedure or the chemotherapy drug (Doxorubicin) used in this trial
• You are currently taking part in another clinical trial involving an experimental drug or device that may interfere with this study
• Your doctor feels that other health conditions you have could affect your ability to safely participate or complete the study (confirm with trial site)
• You are pregnant or currently breastfeeding

Important: Always verify eligibility with the trial site directly before applying.