Depression and Anxiety Trial, By Invitation
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who have tried two or more antidepressant medications (working in different ways) that did not work well enough, and who have been on a stable dose of an antidepressant for more than 6 weeks before joining — with "not working well enough" defined as less than a 50% improvement on a standard depression rating scale (HAMD-24).
- People who score 20 or higher on the 24-item Hamilton Depression Scale (HAMD-24), which is a standard tool used to measure how severe depression is.
- People with normal vision, or vision that is fully corrected (for example, with glasses or contact lenses).
- People who are able to complete a specific visual perception test used in this study (confirm with trial site for details).
- People who have completed at least a college-level education.
- People aged 18 to 45 years, of any gender.
- People who are right-handed.
- People of Han Chinese ethnicity.
- People who have read and signed a written consent form and are willing to take part in the study and its assessments.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have another mental health condition alongside depression, such as schizophrenia, intellectual disability, or substance dependence.
- People who have metal objects inside their body, or any other reason that makes a PET-MRI scan unsafe for them.
- People who have a serious or unstable physical health condition.
- Women who are pregnant or breastfeeding, or women of childbearing age whose urine pregnancy test comes back positive during the screening period.
- People who take benzodiazepine medications (a type of sedative or anti-anxiety medicine) during the study period.
- People whom the study investigators feel, for any other reason, should not take part in this trial.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
Change in Suppression Index after treatment; Change in Suppression Index after treatment; Hamilton Depression Scale (24-items) Total Score Change; Hamilton Depression Scale (24-items) Total Score Change; Change in synaptic density using positron emission tomography/magnetic resonance imaging; Change in synaptic density using positron emission tomography/magnetic resonance imaging
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.