Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are already taking part in the 'CMR versus CT-FFR in CAD' study
- People aged 18 or older
- People who have been referred for an invasive coronary angiography (a procedure to look at the heart's arteries) to investigate chest pain
- People who are willing and able to give their consent to participate
- People who are willing and able to follow all the study requirements, in the opinion of the researchers
- People who agree to allow their GP and relevant specialist to be told about their participation
- People who can read and understand written English
- People who are able to exercise while inside an MRI scanner
- Study arm: People whose CT scan (a special heart imaging test done as part of the research) showed no blockages or narrowing in the heart arteries, but whose MRI stress test showed a problem with blood flow to the heart muscle that suggests a condition called coronary microvascular dysfunction (CMD)
- Control arm: People whose CT scan (done as part of the research) showed narrowing or blockages in more than one heart artery
Who may not be able to join:
- People who have had a heart attack or serious heart event in the past 6 months
- People with severe claustrophobia (extreme fear of enclosed spaces)
- People with certain devices or implants that are not safe or compatible with MRI scanning (note: people with devices that are MRI-conditional or MRI-safe may still be included — confirm with trial site)
- People with a specific type of irregular heart rhythm called second- or third-degree atrioventricular block
- People with severe chronic obstructive pulmonary disease (a serious long-term lung condition)
- People with moderate to severe asthma
- People whose kidneys are not working well enough (based on a specific blood test result below a certain level)
- Women who are pregnant, breastfeeding, or who could become pregnant (premenopausal women)
- People who have a known reaction or allergy to the contrast dye used in CT scans
- People who have taken part in a research study involving an experimental treatment in the past 12 weeks
- People who cannot read or understand written English
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ranjit Arnold, University of Leicester
Phone: +44116 258 3038
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
The ability of coronary luminal volume to myocardial mass (V/M) ratio measured using CT to identify the presence of CMD demonstrated by invasive coronary physiological assessment in patients with angina.; The ability of T1 mapping at rest and exercise to identify the presence of CMD demonstrated by invasive coronary physiological assessment in patients with angina.; The ability of Blood oxygen level-dependent CMR (BOLD-CMR) at rest and exercise at rest and exercise to identify the presence of CMD demonstrated by invasive coronary physiological assessment in patients with angina.; The ability o...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.