Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be willing to take part and sign a consent form after being fully informed about the study
• You must be between 18 and 70 years old
• You must have advanced liver cancer that has been confirmed by a tissue sample (biopsy)
• You must be generally well enough to carry out basic daily activities (a doctor will assess this using a standard scale, scoring 0 or 1)
• You must have cancer that has spread to multiple sites (more than 3), with at least one spot that can be accessed to collect immune cells, confirmed by scans or surgery
• You must have at least one other measurable area of cancer that can be tracked on scans
• Your cancer must have continued to grow or spread after at least two different standard treatments, and no other effective treatments are available
• Your blood counts and organ function (including liver, kidneys, and blood cells) must meet specific healthy levels — a doctor will check these with blood tests
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 7 days before treatment
• You must be able to provide at least 1 gram of fresh tumour tissue and a blood sample for testing
• You are expected to live for at least 3 months
• Your liver function must be at a certain healthy level (Grade A on a standard medical scale) within 7 days before treatment

Who may not be able to join:

• You have, or have had, another active cancer in the past 5 years (with some exceptions — confirm with trial site)
• Your cancer has spread to the brain or spinal cord area
• You have previously had an organ transplant
• You have had major liver surgery within the past 4 weeks (routine biopsy may be an exception — confirm with trial site)
• You have had certain liver treatments (such as chemotherapy delivered through blood vessels, radiation, or tumour burning/freezing) within the past 4 weeks
• Scans have shown serious blockages or unusual blood vessel structure in the arteries near your liver
• Your blood clotting levels are significantly abnormal, or you have had any bleeding in the past 2 months
• You have an active infection that required antibiotics in the past 7 days
• You have had a major operation or serious injury (such as open abdominal or chest surgery) within the past 4 weeks
• You have had serious heart problems, such as a heart attack or newly diagnosed chest pain, within the past 12 months
• You have had a stroke, mini-stroke (TIA), or blood clot in the lungs within the past 12 months
• You have moderate to severe heart failure (confirm with trial site)
• You have HIV, AIDS, or certain untreated active hepatitis infections (B or C)
• You have an active autoimmune disease that requires treatment to suppress your immune system (some stable, well-managed conditions may be acceptable — confirm with trial site)
• You have certain lung diseases or uncontrolled conditions such as diabetes or lung scarring
• You still have significant side effects (grade 2 or higher) from previous cancer treatments, except for anaemia, hair loss, or skin colour changes
• You are pregnant, breastfeeding, or have a positive pregnancy test before starting treatment
• You have serious psychological or psychiatric conditions
• You have taken part in another clinical trial within the past 4 weeks
• You have had a severe allergic reaction to cyclophosphamide or fludarabine (chemotherapy drugs used in this trial)
• The trial team considers you unsuitable for any other medical or safety reason

Important: Always verify eligibility with the trial site directly before applying.