Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been admitted to hospital with a heart attack confirmed by a procedure that looked inside your arteries (a type of X-ray of the heart's blood vessels)
• You had a specific type of heart attack (called STEMI) where symptoms started within 12 hours before arriving at hospital, with particular abnormal readings on a heart tracing (ECG)
• OR you had another type of heart attack (called NSTEMI) where symptoms started within 24 hours before arriving at hospital, confirmed by a blood test showing a raised level of a heart damage marker (troponin)
• For a STEMI heart attack: you are able to receive the study treatment within 36 hours of being admitted to hospital
• For the other type of heart attack (NSTEMI): you are able to receive the study treatment within 72 hours of being admitted to hospital
• You also have at least one of the following in your medical history:
  • A previous heart attack
  • A previous procedure to open or bypass blocked heart arteries
  • Diabetes that is being treated with medication to lower blood sugar
  • A known moderate reduction in kidney function (confirm with trial site for exact levels)
  • A previous stroke caused by a blocked blood vessel in the brain
  • Known narrowing of the neck arteries or blocked arteries in the legs
  • Blockages in more than one heart artery (now or in the past)
  • For STEMI patients only: the current heart attack affected the front part of the heart

Who may not be able to join:

• You received clot-dissolving medication (thrombolytics/fibrinolytics) as treatment for your current heart attack
• You have very severe long-term heart failure (classified as the most serious category, NYHA Class IV)
• Your blood pressure is dangerously low or your heart is not pumping well enough to keep you stable (confirm with trial site for exact definitions)
• Your kidneys are working very poorly — specifically, kidney function is very severely reduced or you are already on kidney dialysis
• You have a significantly elevated liver enzyme level in your blood (a marker of liver damage — confirm with trial site for exact levels)
• You have severe liver disease, including conditions such as confusion caused by liver failure, fluid build-up in the abdomen, yellowing of the skin or eyes, previous bleeding from veins in the food pipe or stomach, or known liver scarring (cirrhosis)
• You have had major heart surgery, non-heart surgery, or a major keyhole procedure in the past 60 days, or you are planned to have major surgery as part of your current heart attack treatment
• You currently have signs or suspicion of an active infection, as judged by the medical team
• You have a known hepatitis B or hepatitis C infection (whether recent or long-term)
• You have untreated hidden (latent) tuberculosis (TB), including a previous positive TB test with TB treatment started less than 28 days before joining the trial, or you are unwilling to have TB treatment if a TB test comes back positive (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.