Phase 2 Liver Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years of age or older
- You have been diagnosed with colorectal cancer that has spread to the liver, confirmed by a biopsy and seen on imaging scans
- You are reasonably active and able to carry out daily activities (confirm with trial site for specific fitness level required)
- You have 3 or fewer liver tumors that can be measured on an MRI scan, with the total combined size under 7 cm and each individual tumor smaller than 5 cm
- Your liver tumors are located a safe distance away from the main blood vessels in your liver (at least 2 cm from the main and branch portal veins)
- Your liver tumors are located at least 1.5 cm away from your stomach or intestines
- Your liver tumors are located at least 0.5 cm away from your diaphragm (the muscle below your lungs)
- Your liver is working well enough, based on blood test results showing normal protein, liver enzyme, and bilirubin levels
- If you are a woman who could become pregnant, you have a negative pregnancy test within 14 days before starting treatment
- You have had prior chemotherapy (including through the liver artery) as long as you stopped at least 2 weeks before joining
- You have had prior targeted therapy or biological treatments as long as you stopped at least 1 week (or longer, depending on the medication) before joining
- You have cancer outside the liver as well — this is still permitted
- You have had previous liver surgery, as long as enough healthy liver tissue remains
- You have had previous radiation to the liver, as long as safe radiation limits can still be met
- Your case has been reviewed by a specialist liver surgical team before enrollment
Who may not be able to join:
- You have a history of cirrhosis (scarring of the liver)
- You have previously had a type of internal radiation treatment for the liver called radioembolization or SIRT
- You have a history of inflammatory bowel disease that makes liver radiation treatment unsafe (confirm with trial site)
- You are currently pregnant or breastfeeding
- You are a man or woman not using effective contraception
- You are unable to have an MRI scan for any reason — for example, if you have certain metal implants, a pacemaker or defibrillator, severe claustrophobia, or an allergy to the contrast dye used in the scan
- You are currently receiving any other cancer treatment within 1 week of starting radiation therapy in this trial
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Marsha Reyngold, MD, PhD, Memorial Sloan Kettering Cancer Center
Phone: 516-559-1527
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Local control rate CRC liver metastasis
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.