Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older.
• People who have been newly diagnosed with a specific type of heart attack (called an anterior wall STEMI) where symptoms started within the last 6 hours, and who are being treated with an emergency procedure to open the blocked artery (called primary PCI).
• People (or their legal representative) who understand what the study involves and have signed a consent form agreeing to take part.
• People whose blocked artery (the one causing the heart attack) is in a native coronary artery with a vessel width estimated to be between 2.25 mm and 4.0 mm.
• People whose blocked artery segment is located in a specific part of the main heart artery (the LAD), between its starting point and the second branch off it (confirm with trial site).
• People whose artery, after initial treatment during the procedure, shows less than 90% blockage remaining and has good blood flow (a specific flow grade called TIMI 3).

Who may not be able to join:

• People who have previously had open-heart bypass surgery (CABG).
• People with a known history of a prior heart attack or prior PCI procedure.
• People who received clot-dissolving medication (thrombolysis) before their PCI procedure.
• People with severe liver or kidney disease, severe heart valve disease, or severe chronic lung disease (COPD).
• People who are unable to have an MRI scan for any reason.
• People with a known allergy to gadolinium contrast dye, or to any medications or materials used in the procedure, including components of drug-eluting stents, all P2Y12 inhibitor medications, or aspirin.
• People whose life expectancy is estimated to be less than 12 months.
• People who are pregnant or breastfeeding.
• People whom the study doctor considers unsuitable for the trial for any other reason.
• People who have other artery blockages that also need to be treated during the same procedure, in addition to the main blocked artery.
• People with significant disease in the left main coronary artery (estimated blockage greater than 50%) that is not protected by a bypass graft.
• People with widespread severe calcium build-up (more than 20 mm) or a completely blocked artery in certain other major heart arteries.
• People with severely twisted or heavily calcified coronary arteries, or other conditions that may interfere with the use of imaging tools inside the artery during the procedure.

Important: Always verify eligibility with the trial site directly before applying.