Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
For people with stable chronic heart failure (CHF):
- People who are at least 18 years old
- People who have been diagnosed with any type of chronic heart failure, are in a stable condition, and have specific blood marker levels (called NT-proBNP) that fall within ranges determined by how well their heart is pumping — the trial site can confirm whether a person's results meet the required levels
For people with acute (sudden or worsening) heart failure (ADHF):
- People who are at least 18 years old
- People who are experiencing symptoms such as breathlessness during activity or at rest, or breathlessness when lying flat, AND have elevated heart failure blood markers or physical signs of fluid build-up in the body (such as swelling in the legs, fluid on the lungs, or raised pressure in the neck veins), AND have shown a response to treatment with fluid-removing medication given through a drip, as assessed by a doctor
For people in the control group:
- People who are at least 18 years old
- People who are having or have had a heart electrical procedure carried out in an electrophysiology (EP) lab (confirm with trial site)
Who may not be able to join:
- People who are currently pregnant or breastfeeding
- People who have a heart condition caused by a protein build-up disease called cardiac amyloidosis
- People who currently have an active cancer diagnosis
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Michail Spanos, MD, Massachusetts General Hospital
Phone: 617-724-4500
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Association between weight change (kg), fluid balance (cumulative fluid intake and output, mL), clinical response to diuretic therapy (as judged by a physician), and salivary biomarker levels assessed by quantitative Polymerase Chain Reaction (qPCR); Rehospitalization event prediction; Association between known biomarkers (NT-proBNP), volume status (right heart catheterization data, echocardiographic data), and salivary biomarker level assessed by qPCR
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.