Phase 2 Cardiomyopathy Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been found to carry a specific genetic change (variant) in one of these genes: PKP2, DSG2, DSC2, DSP, or JUP (note: JUP carriers must have the variant on both copies of the gene), OR you carry a specific variant called TMEM43-p.S358L (confirm with trial site)
- A heart monitor worn for 7 days showed that, on average, you have at least 500 extra/irregular heartbeats (called PVCs) per day
- You have either been diagnosed with a heart condition called ACM (arrhythmogenic cardiomyopathy), or you have been known to be a genetic carrier of a related variant, for at least 6 months before joining the trial
Who may not be able to join:
- You have very severe heart failure (the most advanced stage, known as Class IV)
- You have heart scarring caused by blocked heart arteries (coronary artery disease)
- You have started, stopped, or changed the dose of certain heart rhythm medications (Class I or III anti-arrhythmics) within the last 3 months
- You have a serious long-term liver disease
- A blood test at screening shows your liver enzyme levels (ALT) are more than twice the normal upper limit
- A blood test at screening shows your bilirubin levels (a liver marker) are above the normal upper limit, unless you have a known condition called Gilbert's syndrome — in which case, levels more than twice the upper limit would still exclude you (confirm with trial site)
- You have a history of alcohol or drug use disorders
- You regularly take certain strong medications that affect how the body processes drugs (called strong CYP3A4 inhibitors), such as clarithromycin, ketoconazole, itraconazole, ritonavir, or similar medicines (confirm full list with trial site)
- A blood test shows your kidney function is below a certain level (confirm with trial site)
- You are pregnant at the time of joining the trial
- You are a woman who could become pregnant and are not using a highly effective form of contraception
- You are a man who is sexually active with a woman who could become pregnant and are not using an acceptable form of contraception, unless you have had a surgical procedure making you sterile
- You are unwilling to give your consent to participate or are unable to attend follow-up appointments
- You have a known allergy or sensitivity to the study drug (tideglusib) or any of its ingredients, including an allergy to strawberry
- You are currently taking certain other medications that are processed by the same pathway in the body (CYP3A4) and have a very narrow safe dosing range, such as warfarin or digoxin
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Jason D Roberts, MD MAS, McMaster University and Population Health Research Institute
Phone: 905-521-2100
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
PVC burden
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.