Heart Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are over 18 years old
- People who have been referred to a rapid-access chest pain clinic and, after review, have been identified as needing further heart imaging — either a stress echocardiogram (a type of ultrasound of the heart during exercise) or a CT scan of the heart's arteries — to investigate a possible diagnosis of coronary artery disease (a condition where the arteries supplying the heart become narrowed)
- People whose calculated risk score for coronary artery disease is 5% or higher, based on European Society of Cardiology guidelines
- People whose risk score is below 5% but whose symptoms match what doctors call "typical" chest pain — meaning chest tightness or discomfort in the chest, neck, jaw, shoulder, or arm that occurs during physical activity and goes away with rest or a nitrate medicine (such as GTN spray) within 5 minutes
- People who are willing and able to give their consent to take part in the study and its follow-up appointments
Who may not be able to join:
- People who have been diagnosed with an acute coronary syndrome (a serious, sudden heart condition) that requires urgent or emergency treatment or a hospital stay
- People with a known history of blocked heart arteries, including those who have previously had a heart attack, a stent procedure, bypass heart surgery, or a heart artery scan showing a blockage of 50% or more
- People who have had any type of heart imaging or testing for coronary artery disease (including a coronary calcium score) within the past year
- People with a documented allergy to iodine-based contrast dye, or a documented allergy to both types of ultrasound contrast agents used at the trial site (Luminity® and SonoVue®, or their ingredients)
- People who are unable to undergo a CT heart scan — for example, due to kidney function below a certain level, an allergy to beta-blocker medicines, a significant lung or airways condition, or exceeding the weight limit of the CT scanner
- People who are unable to undergo a stress echocardiogram — for example, due to a specific type of thickened heart muscle condition with significant obstruction, a severe heart valve problem, or severely uncontrolled high blood pressure (180/100mmHg or above)
- People who are pregnant
- People who are unable to give informed consent to participate
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Prof Roxy Senior, LNWH Trust
Phone: 0208 869 2548
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Detection of obstructive CAD and prevalence of MACE in enrolled participants
Can't join this trial?
Data last synced from ClinicalTrials.gov: 7 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.