Liver Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old (any gender)
• People who are willing to take part and are able to sign a consent form on their own
• People diagnosed with advanced liver cancer (hepatocellular carcinoma) confirmed by a tissue or cell sample, at a specific advanced stage, who meet one of these situations: they have already tried at least two rounds of standard treatments (such as targeted therapy, immunotherapy, or chemotherapy) that stopped working or caused intolerable side effects; or their cancer came back or got worse after a local treatment, with at least 4 weeks passed since that treatment; or their cancer came back after surgery and has progressed or was not tolerated after further treatment, with at least 4 weeks passed; or their cancer came back after a liver transplant and has progressed or was not tolerated after further treatment, with at least 4 weeks passed
• People who stopped their last systemic (whole-body) treatment at least 2 weeks before joining the trial
• People whose doctors estimate they are likely to live for more than 6 months
• People who have at least one measurable tumour visible on scans, according to standard measurement guidelines
• People who have tested positive for the Hepatitis B surface antigen now or in the past
• People whose blood test shows a specific immune marker called HLA-A*11:01
• People who either do not have liver scarring (cirrhosis), or have a mild, well-compensated form of it, with a liver function score below 7 (Child-Pugh score) (confirm with trial site)
• People with a physical performance score of 0 or 1 on the ECOG scale, meaning they are fully active or have only minor limitations in physical activity (confirm with trial site)
• People whose blood test results meet all of the following: white blood cell count, liver enzyme levels, bilirubin, kidney function, haemoglobin, platelet count, creatinine, and blood clotting measures are all within the acceptable ranges set by the trial
• Women of childbearing age who have a negative pregnancy test before joining, and all participants who agree to use effective contraception during the trial
• People who agree not to drink alcohol during the study
• People who are willing and able to follow all study procedures and schedules

Who may not be able to join:

• People who currently have a second, separate cancer — except for certain treated skin cancers or curable early-stage cancers such as cervical, bladder, or breast cancer in situ
• People whose liver tumours take up more than 70% of the liver
• People who received a transplant at the same time as another person (co-transplant) (confirm with trial site)
• People who have a blood clot blocking the main portal vein of the liver
• People with a moderate to severe build-up of fluid in the abdomen (ascites)
• People who are HIV-positive, have a history of AIDS, or test positive for syphilis antibodies
• People with advanced liver scarring where the liver is no longer functioning well (decompensated cirrhosis, Child-Pugh score of 7 or above)
• People who have had significant bleeding within the past 2 weeks, or a known tendency to bleed or clot abnormally, or a serious blood vessel event such as stroke, brain bleed, or pulmonary embolism within the past 6 months
• People with high blood pressure that remains above 160/110 mmHg even after taking blood pressure medication
• People whose Hepatitis B viral load in the blood is 1,000 IU/ml or higher at the time of screening (confirm with trial site for transplant-related cases)
• People who test positive for active Hepatitis C virus in the blood
• People who have previously received a cell-based therapy, such as NK, CIK, DC, CTL, or stem cell treatment
• People currently receiving any other cancer treatment, including chemotherapy, hormone therapy, or immunotherapy
• People who have used immune checkpoint inhibitor drugs within the past month
• People with serious heart problems, including severe heart failure or abnormal heart rhythms that cannot be controlled with medication, or a specific heart electrical measurement (QTc interval) that is too long
• People with any other medical condition that could increase their risk or affect the trial results
• People with any condition that would interfere with receiving the study treatment or providing required samples
• People with a history of abusing certain psychiatric drugs and who are unable to stop, or people with a history of mental illness
• People who have taken part in another drug clinical trial within the past 4 weeks
• People who are pregnant or breastfeeding
• People who are unwilling or unable to follow the required study procedures

Important: Always verify eligibility with the trial site directly before applying.