Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed a written consent form before enrolling
• People aged over 18 years old, of any sex
• People who have been diagnosed with intermediate or advanced liver cancer (hepatocellular carcinoma), confirmed by tissue or pathology testing, or people with liver scarring (cirrhosis) whose liver cancer has been diagnosed using recognised international clinical guidelines
• People whose liver cancer has gotten worse while being treated with the combination of camrelizumab and apatinib
• People whose liver is still functioning at a level called "Child-Pugh Class A" (confirm with trial site)
• People with a general health and activity score of 0 or 1 on a standard medical scale (meaning they are fully active or have only minor limitations in physical activity)
• People who have at least one tumour that can be measured using standard imaging guidelines
• People whose doctors expect them to survive for at least 12 weeks
• People whose blood counts, organ function, and other lab results meet specific minimum levels set by the trial (confirm with trial site for full details)
• People with normal blood clotting results and no active bleeding or clotting conditions
• Women who are not surgically sterilised and are of childbearing age must meet additional requirements (confirm with trial site)
• People who are willing to participate fully and attend all required follow-up appointments

Who may not be able to join:

• People whose liver cancer includes certain rare subtypes, such as fibrolamellar, sarcomatoid hepatocellular carcinoma, or bile duct cancer (cholangiocarcinoma), confirmed by testing
• People who have a history of a condition called hepatic encephalopathy (brain problems caused by liver failure)
• People who have previously had a liver transplant
• People with significant fluid build-up around the heart, or fluid around the lungs that is causing symptoms and requires draining
• People who have noticeable fluid build-up in the abdomen (ascites) that can be felt during a physical examination or needs to be drained
• People who are infected with both hepatitis B (HBV) and hepatitis C (HCV) at the same time
• People who have cancer that has spread to the brain or the lining around the brain or spinal cord
• People who have had bleeding from swollen veins in the oesophagus or stomach within the 6 months before starting the trial
• People who have had any significant bleeding event (grade 3 or above on a standard medical scale) within 4 weeks before starting the trial
• People who have had a blood clot in an artery or vein within the 6 months before starting the trial
• People with high blood pressure that is not controlled with medication
• People with heart failure that is causing symptoms
• People with serious bleeding tendencies or blood clotting disorders
• People who have had a hole or abnormal opening in the gastrointestinal tract, or a bowel blockage, within the 6 months before starting the trial
• People with an active autoimmune disease or a history of autoimmune disease (where the immune system attacks the body's own cells)
• People who are living with HIV
• People who, in the trial doctor's judgement, have other serious health conditions that could put them at risk or prevent them from completing the trial

Important: Always verify eligibility with the trial site directly before applying.