Phase 3 Heart Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older (women who could become pregnant must have a negative pregnancy test result)
• People already taking two blood-thinning medications together — aspirin plus a second type called an ADP receptor antagonist — as part of their usual care
• People diagnosed with a heart attack (with or without a specific type called STEMI) within the last 7 days, using the most current medical definition of heart attack
• People who have signed the official consent form agreeing to take part

Who may not be able to join:

• People who have taken the diabetes medication pioglitazone within the last 24 months, or who have taken it for a total of 2 or more years at any point in their life
• People who have taken the diabetes medication rosiglitazone within the last 12 months
• People who have been regularly taking a type of diabetes medication called an SGLT2 inhibitor for more than 15 days in a row at the time of hospital admission
• People who have been regularly taking oral steroid medications at higher doses for more than 30 consecutive days (confirm specific dose thresholds with trial site)
• People with very high blood pressure at the time of enrolment (top number above 180 or bottom number above 100)
• People diagnosed with Type 1 diabetes, a rare inherited form of diabetes called MODY, or diabetes caused by a hormonal condition, pancreatic surgery, medication, a tumour on the pancreas, or long-term pancreatic inflammation
• People with a history of bladder cancer, or who have had radiation treatment to the lower abdomen or pelvis at any point
• People who have had any other cancer in the past 5 years, except for certain non-melanoma skin cancers that were successfully treated
• People with a long-term bladder condition or who have had 3 or more urinary tract infections in the past year
• People with any condition the trial investigator believes would make it unsafe or unsuitable for them to complete the study — this includes certain heart complications, recurring dangerous heart rhythm problems, active cancer (other than a specific type of minor skin cancer), liver cirrhosis, chronic lung disease, or severe autoimmune disease
• People who are pregnant or breastfeeding
• People currently taking part in another clinical trial
• People in septic shock or with severely uncontrolled blood sugar requiring insulin given through a drip at the time of enrolment
• People with significantly elevated liver enzyme or bilirubin levels in their blood tests (confirm specific values with trial site)
• People whose kidneys are not filtering blood well enough (below a specific threshold on a standard kidney function test), or who have had a kidney transplant
• People known to have conditions that cause abnormal blood clotting or an unusually high platelet count
• People with known blood disorders that cause the breakdown of red blood cells
• People with certain abnormal blood count results at the time of enrolment, including low or very high haemoglobin, abnormal white blood cell counts, or platelet counts outside an accepted range (confirm specific values with trial site)

Important: Always verify eligibility with the trial site directly before applying.