Rheumatoid Arthritis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with rheumatoid arthritis using recognised medical guidelines (from 1987 or 2010 standards)
• Your rheumatoid arthritis is currently at a moderate or high level of activity
• You have had a joint tissue sample (biopsy) taken, and the results showed a specific tissue type called "myeloid-stromal pathotype" (confirm with trial site)
• You are willing to follow the trial's requirements, take part fully, and sign a consent form

Who may not be able to join:

• You have taken certain standard arthritis medications (called conventional synthetic DMARDs) in the 12 weeks before joining the trial
• You have received biological therapy (a type of specialist arthritis drug) in the 6 months before joining the trial
• You have previously taken a type of medication called a JAK inhibitor for your arthritis
• You have serious ongoing conditions such as diabetes, serious breathing problems, serious gut or stomach conditions (like recurring ulcers), or serious blood disorders (such as aplastic anaemia or conditions causing red blood cell breakdown)
• You have moderate to severe heart failure, or have had a stroke, heart attack, or coronary stent fitted within the past 6 months, or have uncontrolled high blood pressure
• Your blood test results during screening show abnormally low white blood cell count, low haemoglobin (anaemia), or low platelet count
• You have active liver disease or your liver function blood tests are more than twice the normal limit during screening
• Your kidneys are not filtering blood well enough, based on a specific measurement taken during screening (confirm with trial site)
• You have had a shingles (herpes zoster) infection with symptoms in the past 12 weeks, or have had repeated or widespread shingles or cold sore (herpes simplex) infections at any point
• A chest X-ray or scan shows active or hidden (latent) tuberculosis (TB) that has not been treated preventatively for at least 4 weeks
• You have tested positive for hepatitis C virus, syphilis (Treponema pallidum antibody), or HIV during screening
• You have hepatitis B surface antigen positive and are not receiving preventative antiviral treatment
• You have a history of lymphoma or other lymph gland diseases, or have signs that suggest you might have one
• You have been diagnosed with any cancer in the past 5 years, except for certain treated and cured skin cancers, early-stage cervical cancer, or early-stage breast cancer that has been fully treated
• You have a history of blood clots (such as deep vein thrombosis or pulmonary embolism), or have several risk factors that make blood clots more likely (such as obesity, smoking, clotting problems, or long-term use of certain hormonal treatments — the trial team will assess this)
• You have had major surgery in the 4 weeks before joining, or are expected to need major surgery after joining, or have had an organ transplant, or have long-term pain that might affect how trial results are measured
• You have a history of mental illness, alcohol dependency, or drug or substance misuse
• You are pregnant, breastfeeding, or planning to become pregnant in the near future (applies to both men and women)
• The trial team believes there are any other reasons that might affect your safety or the trial's results

Important: Always verify eligibility with the trial site directly before applying.