Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with liver cancer (hepatocellular carcinoma), either confirmed by a tissue sample or by established medical diagnosis guidelines
• People who have liver cancer that has come back or is still present after previous treatment, with no spread to blood vessels or outside the liver, with all tumours adding up to no more than 5 cm in total size, with no more than 2 tumours in total, and with at least one tumour measurable by standard criteria
• People who have previously had targeted drug therapy or chemotherapy delivered through a vein, as long as that treatment ended at least 6 months before starting this trial
• People aged between 18 and 75 years at the time of diagnosis
• People whose general physical ability and daily functioning is rated at a level indicating they are able to carry out basic self-care (confirm with trial site for exact rating)
• People whose liver is functioning at a healthy enough level, classified as "Child-Pugh class A" (confirm with trial site)
• People who have a healthy liver volume of more than 700 mL
• People with an estimated life expectancy of at least 24 weeks
• People whose blood counts and organ function meet specific minimum levels, including white blood cell counts, platelet counts, haemoglobin, liver enzyme levels, kidney function, and blood protein levels (confirm with trial site for exact values)
• People who are able to understand the study information and agree to take part in writing

Who may not be able to join:

• People who have previously been treated with a type of cancer medicine called immune checkpoint inhibitors
• People whose cancer has spread to areas outside the liver
• People who have had radiotherapy to the abdomen in the past
• People with a known or suspected allergy or sensitivity to monoclonal antibody medicines
• People who have a pre-existing or ongoing condition affecting blood clotting or bleeding
• People who are pregnant or currently breastfeeding
• People who are unable to give informed consent due to psychological, family, social, or other personal circumstances
• People who have had another type of cancer before joining the trial, with the exception of certain skin cancers, early-stage cervical cancer in situ, or prostate cancer that has been fully cured
• People who have had diabetes for more than 10 years and whose blood sugar levels are not well controlled
• People who cannot safely receive radiotherapy due to serious heart, lung, liver, or kidney problems, blood disorders, or significant weight loss and physical decline
• People who have active autoimmune diseases, a history of autoimmune conditions (such as certain types of colitis, hepatitis, or thyroid disorders), a history of immune deficiency including a positive HIV test, other immune system disorders, or a history of organ or bone marrow transplant from a donor
• People who have a history of a lung condition called interstitial lung disease or non-infectious pneumonia
• People who have had active tuberculosis within the past year, or who had active tuberculosis more than a year ago but did not complete proper tuberculosis treatment
• People with active hepatitis B or hepatitis C infection at levels above specified thresholds (confirm with trial site for exact values)
• People with any unstable health situation that could affect their safety or ability to follow the trial requirements

Important: Always verify eligibility with the trial site directly before applying.