Early Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to start a targeted therapy treatment within 1–2 months after receiving a liver transplant.
• People whose anti-rejection medication plan includes three specific drugs: a calcineurin inhibitor, mycophenolate mofetil, and sirolimus.
• People who are willing and able to use reliable contraception throughout the trial and for four weeks after it ends.
• People who are considered "high-risk," which the trial defines as meeting at least one of the following conditions:
  • A PET scan showed positive results before the liver transplant surgery
  • The liver tumour was larger or more widespread than what is called the "UCSF criteria" (confirm with trial site for exact details)
  • The tumour was identified as poorly differentiated (meaning the cancer cells looked very abnormal under a microscope)
  • AFP blood levels did not respond well to standard liver treatments (such as RFA, PEI, or TACE), either dropping less than 15% or remaining above 400 ng/ml

Who may not be able to join:

• People whose life expectancy is estimated to be less than 3 months.
• People who have another type of cancer at the same time.
• People with a known severe allergic reaction to lenvatinib or its ingredients.
• Women who are pregnant or breastfeeding (a pregnancy test within 7 days before treatment starts is required for female participants).
• People with a serious heart condition before surgery, including certain types of heart failure, a heart attack within the past 6 months, difficult-to-control irregular heartbeat, or uncontrolled high blood pressure.
• People with a history of HIV infection.
• People with a serious active infection (confirm with trial site for exact severity level).
• People with epilepsy who require ongoing medication such as steroids or anti-seizure drugs.
• People with kidney disease who require dialysis.
• People with substance use issues, significant mental health conditions, or other personal circumstances that may affect their ability to participate or for results to be properly assessed.
• People who are unable to swallow oral (by mouth) medication, such as those with a severe blockage in the upper digestive tract who need tube feeding.

Important: Always verify eligibility with the trial site directly before applying.