Phase 3 Chronic Rhinosinusitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed by a doctor with chronic rhinosinusitis (long-term sinus inflammation) with nasal polyps in both nostrils.
• You have either had steroid tablets/injections in the last 2 years (or cannot take them due to a medical reason), had surgery for nasal polyps, or both.
• Your nasal polyps are large enough to meet a minimum size score when examined with a small camera inside the nose (confirm with trial site).
• You have had ongoing symptoms for at least 8 weeks before joining, including moderate or severe nasal blockage, plus at least one other symptom such as reduced or total loss of smell, or a runny nose (dripping from the front or back of the nose).
• If you have asthma, it must have been stable and well-controlled for at least 3 months before joining.
• You are a young person aged 12 to 17 years old and weigh at least 40 kg (about 88 lbs).

Who may not be able to join:

• You have previously received a medication called lebrikizumab.
• You needed rescue medication or surgery for nasal polyps during the study screening or run-in period.
• You started allergy immunotherapy (allergy shots or under-the-tongue drops) within the last 6 months and are not yet on a stable dose.
• You have received a biological medicine approved for nasal polyps, asthma, or eczema within the past 4 months or longer (confirm with trial site).
• You have received certain other biological medicines or medicines that suppress the immune system within specific time periods before joining (confirm with trial site for exact timeframes).
• You have had any nasal or sinus surgery, including nasal polyp removal, within 6 months before joining.
• You have had past nasal or sinus surgery that changed the structure of the inside of your nose in a way that makes it hard to assess your polyps (confirm with trial site).
• You have any of the following conditions: a deviated nasal septum blocking at least one nostril, a specific type of polyp called antrochoanal, a current sinus or upper respiratory infection, overuse of nasal decongestant sprays, certain rare conditions linked to nasal polyps (such as cystic fibrosis or specific inflammatory diseases), a nasal tumour (cancerous or non-cancerous), or evidence of a fungal sinus infection.
• Your loss of smell is caused by COVID-19 or any reason other than your nasal polyp condition.
• Your lung function test result (measuring how much air you can breathe out quickly) is 50% or below the normal expected level.
• You are female and are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study.

Important: Always verify eligibility with the trial site directly before applying.