Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with liver cancer (hepatocellular carcinoma) confirmed by a tissue or cell sample, or whose liver cancer has been diagnosed by clinical criteria set by a major liver disease association (AASLD).
• People aged 18 to 75 years old.
• People who have a good general level of physical functioning, rated 0 or 1 on a standard scale used by doctors (ECOG score), meaning they are fully active or have only minor limitations in physical activity.
• People whose liver cancer is at an advanced stage (BCLC stage C), or at an intermediate stage (BCLC stage B) where the cancer has continued to grow despite surgery or local treatments and cannot be effectively controlled by those approaches.
• People whose liver cancer has either gotten worse after at least one prior whole-body (systemic) cancer treatment, or who were unable to tolerate that treatment.
• People who have at least one area of cancer that can be measured on scans according to standard criteria (RECIST v1.1), whether untreated or previously treated locally but showing clear signs of growth.
• People whose liver function is rated as Child-Pugh Level A, meaning the liver is still functioning reasonably well.
• People whose side effects from any previous cancer treatments have either gone back to normal or become stable before joining, except for hair loss.

Who may not be able to join:

• People whose liver cancer has been confirmed as a specific rare type, such as fibrolamellar or sarcomatoid hepatocellular carcinoma.
• People who have a history of hepatic encephalopathy (a condition where the brain is affected by liver disease).
• People who have previously had a liver transplant.
• People who have a significant fluid build-up around the heart (pericardial effusion), or fluid around the lungs (pleural effusion) that requires draining.
• People who have significant fluid build-up in the abdomen (ascites) that can be detected by a physical examination or that needs to be drained.
• People who are infected with both hepatitis B (HBV) and hepatitis C (HCV) at the same time (a past HCV infection with no virus currently detected in the blood may be acceptable — confirm with trial site).
• People who have cancer that has spread to the brain or the lining around the brain or spinal cord.
• People who have had bleeding from varicose veins in the oesophagus or stomach (caused by high blood pressure in the liver's blood vessels) within the 6 months before starting the trial, or who are found to have severe varicose veins (grade 3) on a stomach scope examination required within 6 months before starting.
• People who have any history or current signs of bleeding problems of any severity, or who have had a significant bleeding event (CTCAE grade 3 or higher) within 4 weeks before starting the trial.

Important: Always verify eligibility with the trial site directly before applying.