Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to participate, agree to follow-up visits, and have signed a written consent form
• You are between 18 and 80 years old (any gender)
• You have been officially diagnosed with hepatocellular carcinoma (a type of liver cancer) and have had a tissue sample (biopsy) taken to confirm the diagnosis
• You have at least one tumor that is large enough to be measured on a CT scan, based on specific size guidelines
• You have not received any previous systemic (whole-body) treatment for this cancer
• Your liver cancer is at a certain stage (stages IIa through IIIb based on a Chinese staging system) (confirm with trial site)
• Your cancer is considered "high tumor load," meaning either the number and size of tumors meets a specific threshold, or the cancer has spread into major blood vessels near the liver (confirm with trial site)
• Your liver is functioning at a level rated as Child-Pugh grade A or B with a score of 5–8 (confirm with trial site)
• Your general physical health is rated 0 or 1 on a standard activity scale (meaning you are fully active or have only minor limitations)
• You are expected to live for at least 12 weeks
• If you have an active hepatitis B infection, it is either at a low level or has been treated with antiviral medication for at least one week before starting the trial
• Your blood counts and organ function (blood, liver, and kidney) meet specific minimum levels set by the trial
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 7 days before joining, and you agree to use contraception during the trial and for 8 weeks after the last dose; if you are a man, you agree to use contraception or have had a sterilisation procedure during the trial and for 8 weeks after the last dose

Who may not be able to join:

• You are pregnant or currently breastfeeding
• You have an autoimmune disease, have had an organ or stem cell transplant, or have another active cancer (except certain previously cured skin or cervical cancers)
• You have a mental illness or are unable to cooperate with treatment
• You have taken part in another clinical trial in the past 3 months
• You have received local treatments for your cancer (such as surgery, radiation, or similar procedures) within the past month
• You have had a serious blood clot or stroke event (such as a blood clot in the lung or leg, or a mini-stroke) within the past 6 months — not including blood clots in the portal vein, which are allowed
• You have taken immune-suppressing medications or high-dose steroids within the past 14 days
• You have had bleeding from veins in your oesophagus or stomach within the past month
• You have serious problems with blood clotting that cannot be corrected, or a platelet count that is too low
• You have severe fluid build-up in the abdomen that cannot be controlled
• You have an active infection, especially in the bile ducts
• You have serious failure of the liver, kidneys, heart, lungs, brain, or other major organs
• You have previously used targeted therapy drugs, PD-1 antibody treatments, or similar medications
• You have high blood pressure that cannot be brought under control with medication (above 140/90 mmHg)
• You have a significant heart condition, such as a heart attack, serious irregular heartbeat, or poor heart function
• You have significant levels of protein in your urine
• You are unable to swallow tablets or have a condition that affects how your body absorbs medication
• You have any other condition that the trial doctor believes could put you at risk or prevent you from completing the trial
• You do not wish to have a tissue biopsy to confirm your diagnosis

Important: Always verify eligibility with the trial site directly before applying.