Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 80 years of age
• People who have had a heart attack or severe chest pain (unstable angina) and are planned to have a procedure to open blocked arteries (called PCI, or percutaneous coronary intervention)
• People who have had stents successfully placed in the main blocked artery or arteries causing their symptoms, with less than 20% blockage remaining after the procedure
• People who have at least one other artery with a moderate blockage (40–80% narrowed) that has been assessed using a special blood flow measurement tool and found not to be severely restricting blood flow
• The artery being studied (the "target" artery) must be of a certain size — between 2.0 and 4.0 mm wide and no more than 50 mm in the blocked section
• The target artery must meet at least two specific imaging criteria that suggest the artery wall has features considered higher risk, as assessed by specialised internal imaging of the artery (confirm with trial site for full details)
• People who have given written consent to participate before any study procedures begin

Who may not be able to join:

• People who have a known allergy or intolerance to any of the study medications or device materials — including aspirin, certain blood-thinning medicines, or paclitaxel — that cannot be managed with pre-treatment
• People who are on medicines that suppress the immune system, or who have a serious immune system condition (such as HIV or lupus) requiring ongoing immune-suppressing treatment
• People who have dangerously low blood pressure, are in shock, or need special machines or medicines to support their heart and blood pressure
• People with significantly reduced kidney function (confirm specific threshold with trial site)
• People whose heart is pumping with less than 30% of its normal strength, based on an imaging test done within 30 days before the procedure
• People whose life expectancy is less than 2 years for any reason
• People who are currently taking part in another clinical trial of an experimental drug or device that has not yet finished collecting its main results
• People who have other health, social, or psychological conditions that the trial doctors believe could affect their ability to participate fully or follow up as required
• People whose target artery blockage is located within 10 mm of a previously placed stent (either side)
• People whose target blockage is in the left main coronary artery (the main large artery supplying the heart)
• People whose target blockage is at a point where an artery branches off, if the branch vessel is larger than 2 mm and more than 50% narrowed
• People whose target artery has severe calcium build-up or a very winding, curved shape
• People whose target blockage is within 3 mm of the point where certain major heart arteries begin (the openings of the LAD, LCX, or RCA arteries)
• People whose target blockage is inside a bypass graft artery (an artery placed during previous bypass surgery)

Important: Always verify eligibility with the trial site directly before applying.