Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to sign a consent form agreeing to take part in the study
• People aged between 18 and 85 years old
• People who have been diagnosed with heart failure for at least 3 months before joining, and whose heart failure symptoms fall into a moderate-to-severe range as classified by a standard medical scale (NYHA Class II–IV)
• People who have at least one of the following: signs of heart structural changes (such as an enlarged left atrium or thickened heart wall) seen on an ultrasound of the heart, OR a hospital stay due to heart failure within the 12 months before joining
• People whose heart is still pumping with at least 50% of its normal pumping strength, as measured by a heart ultrasound
• People with a specific heart stress marker (NTpro-BNP) in their blood above a certain level — the required level differs depending on whether or not the person has an irregular heart rhythm called atrial fibrillation (confirm with trial site for exact values)
• People who are taking water pills (diuretics) by mouth must have been on a stable dose for at least 2 weeks before joining
• People who are in a stable condition at the time of being assigned to a treatment group, with no signs of a sudden worsening of their heart failure, as judged by the study doctor

Who may not be able to join:

• People who are currently experiencing a sudden or severe worsening of their heart failure
• People whose kidneys are not filtering blood well enough (a kidney function measure called eGFR is below 30 mL/min/1.73m²)
• People who have significant liver disease, or whose liver enzyme levels (ALT or AST) are more than three times the upper limit of the normal range
• People who have low blood pressure causing symptoms, or whose resting blood pressure reading is below 100 mmHg at the time of joining
• People whose resting heart rate is above 110 beats per minute, as recorded by a heart ultrasound at the screening stage
• People who are currently taking part in another clinical trial of a drug or medical device, or who finished such a trial less than 30 days ago, or who are currently receiving another experimental treatment (note: people in observation-only studies are not excluded)
• People who are currently taking traditional Chinese medicines or patent Chinese medicines that work in a similar way to the study treatment, Qishen Granules
• People who are allergic to any ingredient in Qishen Granules, which contains astragalus membranaceus, salvia miltiorrhiza, and black aconite
• People who refuse to sign the consent form, people who are expected to have difficulty following the study requirements, and women who are pregnant, breastfeeding, or planning to become pregnant during the trial

Important: Always verify eligibility with the trial site directly before applying.