Depression and Anxiety Trial, Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are able to give written consent to participate.
- People aged between 18 and 59 years old.
- People who are generally in good health (apart from their depression diagnosis), as assessed by the study investigator.
- People who live in the community and have a current diagnosis of Major Depressive Disorder, with current depression symptoms falling within a mild-to-moderate range on a standard depression questionnaire (a score of 13–31 on the Beck's Depression Inventory-II).
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have changed their psychiatric medication, or started a new one, less than 2 weeks before the study begins.
- People who have a significant ongoing or serious illness, including heart or digestive conditions (such as irritable bowel, inflammatory bowel disease, or coeliac disease), immune conditions, certain psychiatric conditions (such as bipolar disorder, schizophrenia, or psychosis — though anxiety disorder alone does not exclude someone), neurodevelopmental or neurodegenerative conditions, diabetes (type I or II), or any condition that the investigator believes makes it unsafe to participate in light-to-moderate exercise (confirm with trial site).
- People with a current or advanced cancer diagnosis, or end-stage organ disease.
- People taking certain medications that may interfere with the study, including anti-inflammatory drugs, corticosteroids, laxatives, enemas, proton-pump inhibitors, antibiotics, probiotics (taken within the past month), blood thinners, or over-the-counter pain relief. A four-week wash-out period off these medications would be required before participation could be considered (confirm with trial site).
- People who the investigator believes are unlikely to attend sessions regularly or follow the study requirements.
- People who are currently taking part in another experimental drug trial, or who have completed one within the last 30 days.
- People who are already meeting national physical activity guidelines through structured aerobic exercise (at least 150 minutes of moderate activity per week). Note: if that activity comes only from work or incidental movement, this exclusion may not apply (confirm with trial site).
- Women who are currently in perimenopause, menopause, or post-menopause.
- Women who are pregnant, planning to become pregnant during the study period, or currently breastfeeding.
- People who are not fluent in English or whose first language is not English.
- People who are colour blind.
- People who have dyslexia or dyscalculia.
- People who currently smoke every day.
- People who regularly use illegal drugs.
- People with an alcohol use disorder.
- People who are currently experiencing active thoughts of suicide, or who have made a suicide attempt in the past 6 months.
- People with a current eating disorder, including anorexia nervosa, bulimia nervosa, or binge eating disorder.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Gerard Clarke, PhD, University College Cork, APC Microbiome Ireland
Phone: (+353) 021 4901721
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
This date has passed while the registry still lists the trial as open to participants. Sponsors often update a trial's status without revising its projected end date, so it may well still be recruiting — but the record is out of date in at least one respect. Check with the study contact before relying on either.
Where this trial is recruiting
Primary endpoints
Depression symptom change; Negative and positive affect change; Gut microbiota change; Cognitive performance: affective perceptual bias; Cognitive performance: social cognition
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.