Phase 2 HIV and AIDS Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have a confirmed diagnosis of Kaposi Sarcoma (proven by biopsy) with lesions that can be measured with a ruler.
• People who have either two lesions at least 4mm x 4mm in size, or one lesion at least 8mm x 8mm in size, that can be biopsied — plus at least 5 additional lesions elsewhere.
• People aged 18 or older.
• People who weigh at least 40 kg (approximately 88 pounds).
• People who are reasonably able to carry out daily activities (a doctor will assess this using a standard scale called the ECOG scale, with a score of 2 or less required) (confirm with trial site).
• People who are HIV-positive and have been on HIV treatment (antiretroviral therapy) for at least 12 weeks, meeting specific conditions about how long they have been on treatment and whether their Kaposi Sarcoma has been changing.
• People who are HIV-negative and whose Kaposi Sarcoma has not been improving in the 12 weeks before joining the trial.
• Women who could become pregnant must agree to use reliable contraception before, during, and for one month after taking part in the trial, and must report a suspected pregnancy to their treating doctor immediately.
• People who are able to swallow an oral pill.
• People who are willing and able to understand and sign a written consent form approved by an ethics review board.

Who may not be able to join:

• People whose Kaposi Sarcoma has spread to internal organs in a way that is affecting how those organs function.
• People who urgently need to start strong chemotherapy right away (though people who received chemotherapy more than 4 weeks before screening may still be considered).
• People with another cancer (past or current) that could interfere with assessing how safe or effective the trial treatment is.
• People who are currently taking a type of heart/blood pressure medication called beta-blockers for another condition (previous use may be allowed if stopped long enough before the trial starts — confirm with trial site).
• People who are currently receiving any other cancer treatment, or who have received cancer treatment within the past 4 weeks.
• People who are currently taking part in another clinical trial involving an investigational treatment.
• People who have had an allergic reaction to propranolol or to medications with a similar chemical make-up.
• People with a history of asthma, COPD, or other breathing airway conditions — though people with mild or well-controlled cases who have not had a flare-up requiring extra treatment in the past 3 months may still be considered.
• People with a history of diabetes, as identified by specific blood sugar measurements (confirm with trial site for the specific values).
• People with a history of heart failure that is not well managed, a very slow heart rate (persistently below 50 beats per minute), certain heart rhythm problems, or significant heart conduction issues — though people with a mildly slow but stable heart rate of at least 51 beats per minute and no symptoms may be considered.
• People with a history of low blood pressure or significant drops in blood pressure when standing up — though isolated incidents may be discussed with the trial doctor.
• People experiencing shortness of breath, coughing up blood, or a moderate to severe cough that cannot be explained by causes other than Kaposi Sarcoma — though those with minor, temporary symptoms and healthy oxygen levels may be considered.
• People experiencing bleeding from the mouth or rectum that cannot be explained by causes other than Kaposi Sarcoma, unless it is minor and temporary (such as slight blood on toilet paper).
• People with uncontrolled ongoing illness, such as a significant active infection, unstable heart conditions, or serious heart rhythm problems.
• People currently showing signs of a serious condition called KSHV inflammatory cytokine syndrome (people with a past history of this condition may still be considered).
• People who are pregnant or breastfeeding; women who could become pregnant must have a negative pregnancy test within 21 days of joining.
• People with an untreated or inadequately treated active Hepatitis B virus (HBV) infection (those receiving HBV treatment or with an undetectable viral load on treatment may be considered; testing is not required unless there is a known history of infection).
• People with a current or uncured Hepatitis C virus (HCV) infection with a detectable viral load (those who have been treated and cured, or who are on treatment with an undetectable viral load, may be considered; testing is not required unless there is a known history of infection).

Important: Always verify eligibility with the trial site directly before applying.