Phase 1 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to read and sign a consent form agreeing to take part in the study.
• You are between 18 and 75 years old.
• You have a specific genetic marker called HLA-A 02:03 (this would be confirmed through a blood test).
• You have been diagnosed with liver cancer (hepatocellular carcinoma) or another solid tumour that produces a protein called AFP, confirmed by a tissue sample, and surgery or local treatments are not expected to help you, and you have already tried at least one course of treatment.
• Your tumour tissue samples or a blood test show a high level of the AFP protein.
• Your liver cancer is at a certain stage of severity (Barcelona stage B or C) and your liver is functioning at an acceptable level (confirm with trial site).
• You are generally well enough to carry out light activities and care for yourself (assessed using a standard scale).
• Your doctors estimate you are likely to live for at least 4 more months.
• You have at least one tumour that can be measured on a scan.
• Your blood counts, liver function, kidney function, heart function, and oxygen levels are all within acceptable ranges (confirm with trial site for specific values).
• If you could become pregnant, you must agree to use effective contraception throughout the trial and for at least 1 year after treatment, and have a negative pregnancy test before a blood collection procedure.

Who may not be able to join:

• You still have significant side effects from a previous cancer treatment that have not cleared up or reduced to a mild level.
• You have had another separate cancer diagnosis within the last 5 years (some exceptions may apply for certain early-stage cancers that were fully removed — confirm with trial site).
• You have had a serious heart condition or a significant brain or nervous system disorder in the 6 months before joining the study.
• You have an autoimmune disease (where your immune system attacks your own body) that requires long-term medication to suppress your immune system.
• You have had an allergic reaction to the drugs cyclophosphamide or fludarabine, or are known to be allergic to any component used in this trial's treatment.
• You have had, or currently have, a condition where the liver is unable to remove toxins from the blood, causing confusion or other brain-related symptoms (hepatic encephalopathy).
• You have previously had an organ transplant or a transplant using cells from another person.
• You have had bleeding in your stomach or intestines, or a significant risk of such bleeding, in the last 3 months.
• You have a condition that causes problems with bleeding or blood clotting, whether inherited or developed over time.
• You currently have an active infection or an unexplained fever.
• You have cancer that has spread to your brain or nervous system and is causing symptoms.
• You have a known HIV or syphilis infection, or an active hepatitis C infection.
• You have hepatitis B with a virus level in your blood that is above a certain amount (confirm with trial site).
• You are pregnant or breastfeeding, or a pregnancy test comes back positive before you join.
• You have uncontrolled diabetes, or certain serious lung or liver conditions (confirm with trial site for details).

Important: Always verify eligibility with the trial site directly before applying.