Phase 4 Heart Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Men between 18 and 55 years old, or women between 18 and 65 years old.
• People diagnosed with coronary artery disease (blockages in the heart's arteries), where imaging has confirmed narrowing in 2 or more arteries, with at least one artery having a 50–70% blockage.
• People with LDL ("bad") cholesterol above 3.4 mmol/L who are not on regular cholesterol-lowering medication, OR people with LDL cholesterol above 1.8 mmol/L after 4 weeks of taking statin (cholesterol-lowering) medication.

Who may not be able to join:

• People with known allergies or medical reasons they cannot take PCSK9 inhibitor medications and/or statin medications.
• People who have previously used PCSK9 inhibitor medications.
• People who have previously had a bleeding stroke (a stroke caused by bleeding in the brain).
• People who have previously had heart bypass surgery or any procedure to open blocked heart arteries.
• People for whom a specific type of heart artery imaging (called OCT) cannot be performed, or where the imaging results are not clear enough to use.
• People with severely reduced kidney function (confirm with trial site for specific test values).
• People with severe liver problems.
• People with very high triglyceride (a type of fat in the blood) levels above 5.6 mmol/L at the start of the trial.
• Women who are pregnant or breastfeeding.
• People whose life expectancy is estimated at one year or less.
• People the trial investigators consider unsuitable for the study for any reason.

Important: Always verify eligibility with the trial site directly before applying.