Depression and Anxiety Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People of any gender identity (male, female, or diverse)
- People aged between 18 and 65 years
- People diagnosed with moderate to severe major depression according to standard psychiatric criteria (DSM-5)
- People with a depression symptom score of 20 or more on a standard rating scale called the MADRS
- People whose current depressive episode has lasted at least 2 weeks but no longer than 2 years
- People who have not previously taken antidepressant medication and for whom antidepressant treatment is considered appropriate
- People who are able to understand and agree to take part in the study (give informed consent)
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People currently experiencing serious thoughts of suicide (as measured by a specific item on the MADRS rating scale)
- People experiencing symptoms of psychosis (such as hallucinations or delusions)
- People currently taking anti-seizure medications or sedative medications (benzodiazepines) above a certain dose level
- People with an additional major psychiatric diagnosis alongside depression, with the exception of anxiety disorders
- People with a severe personality disorder that is considered a primary concern
- People whose depression has already not responded to at least one adequate antidepressant treatment in the current or a previous episode
- People with certain neurological conditions, including serious brain injury, brain tumours, previous brain surgery, a stroke within the last 3 months, neurodegenerative diseases, epilepsy, or a history of seizures
- People who have a cardiac pacemaker, as this is not compatible with MRI scanning
- People who have metal implants inside the skull
- People who have previously received a treatment called rTMS (repetitive transcranial magnetic stimulation)
- People who have a device for deep brain stimulation
- People with other serious physical health conditions, or who are pregnant
- People for whom the study medication (escitalopram) is medically unsuitable (confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Phone: +4970712984858
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
response rates after Stage I
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.