Phase 4 Heart Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For patients being assessed for heart conditions:

• The person has agreed in writing to take part in the trial
• The person has been referred to the Department of Clinical Physiology at Skåne University Hospital for a suspected or confirmed chronic coronary condition or heart failure
• The person falls within the required age and sex balance — the trial is looking for equal numbers of men and women in each decade of age from 40 years old up to over 80 years old
• The person either has no known heart failure, or has a known heart failure diagnosis (two separate groups)
• The person has not had any caffeine in the 24 hours before the examination

For healthy volunteers:

• The person has agreed in writing to take part in the trial
• The person falls within the required age and sex balance — equal numbers of men and women in each decade of age from 40 years old up to over 80 years old
• The person has not had any caffeine in the 24 hours before the examination

Who may not be able to join:

For patients:

• The person has been referred as an emergency or is currently admitted as an inpatient
• The person is currently in an unstable medical condition
• The person is experiencing acute (sudden or severe) chest pain
• The person has severe or currently worsening heart failure
• The person has an irregular heart rhythm, such as atrial fibrillation, rather than a normal sinus rhythm
• The person has asthma or severe chronic lung disease
• The person has known long-term kidney disease with significantly reduced kidney function (eGFR below 45mL/min/1.73m²) (confirm with trial site)
• The person has a specific type of heart conduction problem known as AV-block grade II or III (confirm with trial site)
• The person has a heart conduction problem called Left Bundle Branch Block (confirm with trial site)
• The person has a resting blood pressure that is either too low (below 90 mmHg systolic) or too high (above 230 mmHg systolic)
• The person has raised pressure inside the skull
• The person has a known allergy or previous bad reaction to the medications adenosine or mannitol
• The person has a known allergy or previous bad reaction to gadolinium contrast dye used in MRI scans
• The person is currently taking medication that contains dipyridamole, theophylline, or related compounds (confirm with trial site)
• The person experiences claustrophobia (fear of enclosed spaces)
• The person has a medical device in their body that is not safe for MRI scanning, such as a pacemaker, certain implants, or clips in the brain
• The person is pregnant or breastfeeding (assessed by self-reported questions only)
• The person is unable to give informed consent due to their mental state, language barriers, or similar reasons

For healthy volunteers, all of the above apply, plus:

• The person has a blood pressure reading above 140/90, measured using standard clinical methods
• The person has a known ongoing condition affecting the whole body (systemic disease)
• The person has any known heart condition
• The person is currently taking any medication for the heart or blood vessels
• The person is currently taking any medication that could affect heart or blood vessel health
• The person smokes

Important: Always verify eligibility with the trial site directly before applying.